Unique pulmonary antigen presentation may call for an alternative approach toward lung cancer immunotherapy

被引：6

作者：

Chang, Stephanie

Lin, Xue

Higashikubo, Ryuji

Toth, Kelsey

Gelman, Andrew E.

Kreisel, Daniel

Krupnick, Alexander S. ^{[1
]}

机构：

[1] Washington Univ, Sch Med, Alvin Siteman Canc Ctr, Dept Surg,Div Cardiothorac Surg, St Louis, MO 63130 USA

来源：

ONCOIMMUNOLOGY | 2013年 / 2卷 / 03期

关键词：

natural killer cells; lung cancer; mucosal antigen presentation; immunotherapy; adoptive immune system; T-CELL RESPONSES; PHASE-III TRIAL; ADOPTIVE TRANSFER; KILLER-CELLS; TUMOR; LYMPHOCYTES;

D O I：

10.4161/onci.23563

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 [肿瘤学];

摘要：

Unlike other tumors, lung cancer appears to be poorly sensitive to immunotherapy. We have recently demonstrated an alternative pathway of lung cancer immunosurveillance. Our data indicate a failure of the adaptive immune system to mediate the immunosurveillance of lung cancer and emphasize the prominent role of natural killer cells in this setting.

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