Open-vessel microwave-promoted Suzuki reactions using low levels of palladium catalyst: Optimization and scale-up

被引：61

作者：

Leadbeater, Nicholas E.

Williams, Victoria A.

Barnard, Thomas M.

Collins, Michael J., Jr.

机构：

[1] Univ Connecticut, Dept Chem, Unit 3060, Storrs, CT 06269 USA

[2] CEM Microwave Technol, Matthews, NC 28104 USA

来源：

ORGANIC PROCESS RESEARCH & DEVELOPMENT | 2006年 / 10卷 / 04期

关键词：

D O I：

10.1021/op0600613

中图分类号：

O69 [应用化学];

学科分类号：

081704 ;

摘要：

Representative Suzuki couplings in water using low catalyst concentrations in conjunction with microwave heating have been transferred from sealed-vessel to open-vessel reaction conditions. They have then been scaled-up to the mole scale using a dedicated multimode microwave apparatus. The reactions are complete within 20 min of heating at reflux.

引用

收藏

页码：833 / 837

页数：5

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