Design considerations for high speed quantitative mass spectrometry with MALDI ionization

被引：61

作者：

Corr, Jay J. ^{[1
]}

Kovarik, Peter ^{[1
]}

Schneider, Bradley B. ^{[1
]}

Hendrikse, Jan ^{[1
]}

Loboda, Alexander ^{[1
]}

Covey, Thomas R. ^{[1
]}

机构：

[1] MDS SCIEX, Concord, ON L4K 4V8, Canada

来源：

JOURNAL OF THE AMERICAN SOCIETY FOR MASS SPECTROMETRY | 2006年 / 17卷 / 08期

关键词：

D O I：

10.1016/j.jasms.2006.04.026

中图分类号：

Q5 [生物化学];

学科分类号：

071010 ; 081704 ;

摘要：

A MALDI ion source on a triple quadrupole mass spectrometer constructed for the purpose of obtaining high speed quantitative measurements on drugs and other low molecular weight compounds is described. Particular attention is given to the ion generation and transport phenomena that affect analysis speed, throughput, and practical instrument robustness. In this regard parameters that affect desorption speed, beam spreading, ion flight times, sensitivity, signal-to-noise, ion fragmentation, sample carry-over, and instrument contamination are examined and experimental results are provided. MALDI and electrospray sensitivity is compared, to provide a practical frame of reference.

引用

页码：1129 / 1141

页数：13

共 33 条

[1] INFLUENCE OF THE LASER-BEAM DIRECTION ON THE MOLECULAR ION EJECTION ANGLE IN MATRIX-ASSISTED LASER-DESORPTION IONIZATION [J].