A census of human RNA-binding proteins

被引：1490

作者：

Gerstberger, Stefanie ^{[1
,2
]}

Hafner, Markus ^{[3
]}

Tuschl, Thomas ^{[1
,2
]}

机构：

[1] Rockefeller Univ, Howard Hughes Med Inst, New York, NY 10065 USA

[2] Rockefeller Univ, Lab RNA Mol Biol, New York, NY 10065 USA

[3] NIAMSD, Lab Muscle Stem Cells & Gene Regulat, NIH, Bethesda, MD 20892 USA

来源：

NATURE REVIEWS GENETICS | 2014年 / 15卷 / 12期

关键词：

EUKARYOTIC STRESS GRANULES; AICARDI-GOUTIERES-SYNDROME; SHOCK DOMAIN PROTEINS; MESSENGER-RNA; GENE-EXPRESSION; RIBOSOME BIOGENESIS; STRANDED-RNA; ALTERNATIVE POLYADENYLATION; STRUCTURAL CLASSIFICATION; TRANSLATIONAL CONTROL;

D O I：

10.1038/nrg3813

中图分类号：

Q3 [遗传学];

学科分类号：

071007 ; 090102 ;

摘要：

Post-transcriptional gene regulation (PTGR) concerns processes involved in the maturation, transport, stability and translation of coding and non-coding RNAs. RNA-binding proteins (RBPs) and ribonucleoproteins coordinate RNA processing and PTGR. The introduction of large-scale quantitative methods, such as next-generation sequencing and modern protein mass spectrometry, has renewed interest in the investigation of PTGR and the protein factors involved at a systems-biology level. Here, we present a census of 1,542 manually curated RBPs that we have analysed for their interactions with different classes of RNA, their evolutionary conservation, their abundance and their tissue-specific expression. Our analysis is a critical step towards the comprehensive characterization of proteins involved in human RNA metabolism.

引用

页码：829 / 845

页数：17

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