共 22 条
Lewis acid-promoted addition of methylenecyclopropanes to aldehydes and ketones
被引:23
作者:
Miura, K
[1
]
Takasumi, M
[1
]
Hondo, T
[1
]
Saito, H
[1
]
Hosomi, A
[1
]
机构:
[1] UNIV TSUKUBA,DEPT CHEM,TSUKUBA,IBARAKI 305,JAPAN
关键词:
D O I:
10.1016/S0040-4039(97)00981-7
中图分类号:
O62 [有机化学];
学科分类号:
070303 ;
081704 ;
摘要:
In the presence of TiCl4, methylenecyclopropane (1a) easily reacted with aliphatic aldehydes to give the beta-(chloromethyl)allylated products 2 in good yields along with a small amount of the methylenetetrahydrofurans 3. The reaction with chiral alpha- and beta-alkoxy aldehydes proceeded with high levels of chelation control. (C) 1997 Elsevier Science Ltd.
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页码:4587 / 4590
页数:4
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