Lewis acid-promoted addition of methylenecyclopropanes to aldehydes and ketones

被引：23

作者：

Miura, K ^{[1
]}

Takasumi, M ^{[1
]}

Hondo, T ^{[1
]}

Saito, H ^{[1
]}

Hosomi, A ^{[1
]}

机构：

[1] UNIV TSUKUBA,DEPT CHEM,TSUKUBA,IBARAKI 305,JAPAN

来源：

TETRAHEDRON LETTERS | 1997年 / 38卷 / 26期

关键词：

D O I：

10.1016/S0040-4039(97)00981-7

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

In the presence of TiCl4, methylenecyclopropane (1a) easily reacted with aliphatic aldehydes to give the beta-(chloromethyl)allylated products 2 in good yields along with a small amount of the methylenetetrahydrofurans 3. The reaction with chiral alpha- and beta-alkoxy aldehydes proceeded with high levels of chelation control. (C) 1997 Elsevier Science Ltd.

引用

页码：4587 / 4590

页数：4