Relationship between genome and epigenome - challenges and requirements for future research

被引：19

作者：

Almouzni, Genevieve ^{[1
]}

Altucci, Lucia ^{[2
]}

Amati, Bruno ^{[3
,4
]}

Ashley, Neil ^{[5
]}

Baulcombe, David ^{[6
]}

Beaujean, Nathalie ^{[7
]}

Bock, Christoph ^{[8
]}

Bongcam-Rudloff, Erik ^{[9
]}

Bousquet, Jean ^{[10
]}

Braun, Sigurd ^{[11
]}

Bressac-de Paillerets, Brigitte ^{[12
]}

Bussemakers, Marion ^{[13
]}

Clarke, Laura ^{[14
]}

Conesa, Ana ^{[15
]}

Estivill, Xavier ^{[16
,17
]}

Fazeli, Alireza ^{[18
]}

Grgurevic, Neza ^{[19
,20
]}

Gut, Ivo ^{[21
]}

Heijmans, Bastiaan T. ^{[22
]}

Hermouet, Sylvie ^{[23
]}

Houwing-Duistermaat, Jeanine ^{[22
]}

Iacobucci, Ilaria ^{[24
]}

Ilas, Janez ^{[19
,20
]}

Kandimalla, Raju ^{[25
]}

Krauss-Etschmann, Susanne ^{[26
]}

Lasko, Paul ^{[27
]}

Lehmann, Soeren ^{[28
]}

Lindroth, Anders ^{[29
]}

Majdic, Gregor ^{[19
,20
]}

Marcotte, Eric ^{[30
]}

Martinelli, Giovanni ^{[24
]}

Martinet, Nadine ^{[31
]}

Meyer, Eric ^{[32
]}

Miceli, Cristina ^{[33
]}

Mills, Ken ^{[34
]}

Moreno-Villanueva, Maria ^{[35
]}

Morvan, Ghislaine ^{[36
]}

Nickel, Doerthe ^{[1
]}

Niesler, Beate ^{[37
]}

Nowacki, Mariusz ^{[38
]}

Nowak, Jacek ^{[39
]}

Ossowski, Stephan ^{[16
,17
]}

Pelizzola, Mattia ^{[3
]}

Pochet, Roland ^{[40
]}

Potocnik, Uros ^{[41
]}

Radwanska, Magdalena ^{[42
]}

Raes, Jeroen ^{[43
,44
,45
]}

Rattray, Magnus ^{[46
]}

Robinson, Mark D. ^{[47
]}

Roelen, Bernard ^{[48
]}

机构：

[1] Inst Curie Res Ctr, CNRS IC, UMR3664, F-75248 Paris 05, France

[2] Univ Naples 2, Naples, Italy

[3] IIT, Milan, Italy

[4] IEO, Milan, Italy

[5] Univ Oxford, Oxford, England

[6] Univ Cambridge, Cambridge, England

[7] INRA, UMR 1198 Biol Dev & Reprod, F-78350 Jouy En Josas, France

[8] Austrian Acad Sci, CeMM Res Ctr Mol Med, A-1010 Vienna, Austria

[9] Swedish Univ Agr Sci, Uppsala, Sweden

[10] Univ Montpellier, F-34059 Montpellier, France

[11] Univ Munich, Munich, DE, Germany

[12] Gustave Roussy, Villejuif, France

[13] Radboud Univ Nijmegen, NL-6525 ED Nijmegen, Netherlands

[14] European Bioinformat Inst Hinxton, European Mol Biol Lab, Cambridge, England

[15] Ctr Invest Principe Felipe, Valencia, Spain

[16] CRG, Barcelona, Spain

[17] UPF, Barcelona, Spain

[18] Univ Sheffield, Sheffield, S Yorkshire, England

[19] Univ Ljubljana, Inst Physiol, Fac Vet, Ctr Anim Gen, Ljubljana, Slovenia

[20] Univ Ljubljana, Sch Med, Ljubljana, Slovenia

[21] Ctr Nacl Anal Genom, Barcelona, Spain

[22] Leiden Univ, Med Ctr, Leiden, Netherlands

[23] Ctr Hosp Univ, Nantes, France

[24] Univ Bologna, Bologna, Italy

[25] UCL, UCL Elizabeth Garrett Anderson Inst Womens Hlth, Dept Womens Canc, London WC1E 6AU, England

[26] Helmholtz Ctr, Munich, Germany

[27] McGill Univ, Dept Biol, Montreal, PQ H3A 1B1, Canada

[28] Karolinska Inst, Stockholm, Sweden

[29] German Canc Res Ctr, Heidelberg, Germany

[30] Canadian Inst Hlth Res, Ottawa, ON, Canada

[31] CNRS, Inst Chim, CNRS UNSA 7272, F-06034 Nice, France

[32] CNRS, Paris, France

[33] Univ Camerino, I-62032 Camerino, Italy

[34] Queens Univ Belfast, Belfast, Antrim, North Ireland

[35] Univ Konstanz, Constance, Germany

[36] Museum Natl Hist Nat, CNRS, UMR7221, F-75231 Paris, France

[37] Univ Klinikum Heidelberg, Heidelberg, Germany

[38] Univ Bern, Bern, Switzerland

[39] PAS, Inst Biochem & Biophys, Warsaw, Poland

[40] Univ Libre Brussels, Brussels, Belgium

[41] Univ Maribor, SLO-2000 Maribor, Slovenia

[42] Sci Europe, Brussels, Belgium

[43] Vrije Univ Brussel, Brussels, Belgium

[44] Katholieke Univ Leuven, Leuven, Belgium

[45] Vlaams Inst Biotechnol, Ghent, Belgium

[46] Univ Manchester, Manchester, Lancs, England

[47] Univ Zurich, Zurich, Switzerland

[48] Univ Utrecht, Utrecht, Netherlands

[49] Max Planck Inst Mol Genet, D-14195 Berlin, Germany

[50] Univ Magdeburg, D-39106 Magdeburg, Germany

来源：

BMC GENOMICS | 2014年 / 15卷

关键词：

Genome; Epigenome; Microbiome; Environment; DNA METHYLATION; STEM-CELLS; INHIBITION; CANCER; DEATH;

D O I：

10.1186/1471-2164-15-487

中图分类号：

Q81 [生物工程学（生物技术）]; Q93 [微生物学];

学科分类号：

071005 [微生物学]; 090105 [作物生产系统与生态工程];

摘要：

Understanding the links between genetic, epigenetic and non-genetic factors throughout the lifespan and across generations and their role in disease susceptibility and disease progression offer entirely new avenues and solutions to major problems in our society. To overcome the numerous challenges, we have come up with nine major conclusions to set the vision for future policies and research agendas at the European level.

引用

页数：7

共 20 条

[1]

BLUEPRINT to decode the epigenetic signature written in blood [J].

Adams, David ;

Altucci, Lucia ;

Antonarakis, Stylianos E. ;

Ballesteros, Juan ;

Beck, Stephan ;

Bird, Adrian ;

Bock, Christoph ;

Boehm, Bernhard ;

Campo, Elias ;

Caricasole, Andrea ;

Dahl, Fredrik ;

Dermitzakis, Emmanouil T. ;

Enver, Tariq ;

Esteller, Manel ;

Estivill, Xavier ;

Ferguson-Smith, Anne ;

Fitzgibbon, Jude ;

Flicek, Paul ;

Giehl, Claudia ;

Graf, Thomas ;

Grosveld, Frank ;

Guigo, Roderic ;

Gut, Ivo ;

Helin, Kristian ;

Jarvius, Jonas ;

Kueppers, Ralf ;

Lehrach, Hans ;

Lengauer, Thomas ;

Lernmark, Ake ;

Leslie, David ;

Loeffler, Markus ;

Macintyre, Elizabeth ;

Mai, Antonello ;

Martens, Joost H. A. ;

Minucci, Saverio ;

Ouwehand, Willem H. ;

Pelicci, Pier Giuseppe ;

Pendeville, Helene ;

Porse, Bo ;

Rakyan, Vardhman ;

Reik, Wolf ;

Schrappe, Martin ;

Schuebeler, Dirk ;

Seifert, Martin ;

Siebert, Reiner ;

Simmons, David ;

Soranzo, Nicole ;

Spicuglia, Salvatore ;

Stratton, Michael ;

Stunnenberg, Hendrik G. .

NATURE BIOTECHNOLOGY, 2012, 30 (03) :224-226

[2]

Understanding the complexity of IgE-related phenotypes from childhood to young adulthood: A Mechanisms of the Development of Allergy (MeDALL) Seminar [J].

Anto, Josep M. ;

Pinart, Mariona ;

Akdis, Muebeccel ;

Auffray, Charles ;

Bachert, Claus ;

Basagana, Xavier ;

Carlsen, Kai-Hakon ;

Guerra, Stefano ;

von Hertzen, Leena ;

Illi, Sabina ;

Kauffmann, Francine ;

Keil, Thomas ;

Kiley, James P. ;

Koppelman, Gerard H. ;

Lupinek, Christian ;

Martinez, Fernando D. ;

Nawijn, Martijn C. ;

Postma, Dirkje S. ;

Siroux, Valerie ;

Smit, Henriette A. ;

Sterk, Peter J. ;

Sunyer, Jordi ;

Valenta, Rudolf ;

Valverde, Sergio ;

Akdis, Cezmi A. ;

Annesi-Maesano, Isabella ;

Ballester, Ferran ;

Benet, Marta ;

Cambon-Thomsen, Anne ;

Chatzi, Leda ;

Coquet, Jonathan ;

Demoly, Pascal ;

Gan, Weiniu ;

Garcia-Aymerich, Judith ;

Gimeno-Santos, Elena ;

Guihenneuc-Jouyaux, Chantal ;

Haahtela, Tari ;

Heinrich, Joachim ;

Herr, Marie ;

Hohmann, Cynthia ;

Jacquemin, Benedicte ;

Just, Jocelyne ;

Kerkhof, Marjan ;

Kogevinas, Manolis ;

Kowalski, Marek L. ;

Lambrecht, Bart N. ;

Lau, Susanne ;

Carlsen, Karin C. Lodrup ;

Maier, Dieter ;

Momas, Isabelle .

JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY, 2012, 129 (04) :943-U421

[3]

BARKER DJP, 1989, LANCET, V2, P577

[4]

Perceptions of epigenetics [J].

Bird, Adrian .

NATURE, 2007, 447 (7143) :396-398

[5]

Quantitative comparison of genome-wide DNA methylation mapping technologies [J].

Bock, Christoph ;

Tomazou, Eleni M. ;

Brinkman, Arie B. ;

Mueller, Fabian ;

Simmer, Femke ;

Gu, Hongcang ;

Jaeger, Natalie ;

Gnirke, Andreas ;

Stunnenberg, Hendrik G. ;

Meissner, Alexander .

NATURE BIOTECHNOLOGY, 2010, 28 (10) :1106-U196

[6]

HDAC modulation and cell death in the clinic [J].

Dell'Aversana, Carmela ;

Lepore, Ilaria ;

Altucci, Lucia .

EXPERIMENTAL CELL RESEARCH, 2012, 318 (11) :1229-1244

[7]

Epigenetic changes in cancer [J].

Gronbaek, Kirsten ;

Hother, Christoffer ;

Jones, Peter A. .

APMIS, 2007, 115 (10) :1039-1059

[8]

Whole-Genome Bisulfite Sequencing of Two Distinct Interconvertible DNA Methylomes of Mouse Embryonic Stem Cells [J].

Habibi, Ehsan ;

Brinkman, Arie B. ;

Arand, Julia ;

Kroeze, Leonie I. ;

Kerstens, Hindrik H. D. ;

Matarese, Filomena ;

Lepikhov, Konstantin ;

Gut, Marta ;

Brun-Heath, Isabelle ;

Hubner, Nina C. ;

Benedetti, Rosaria ;

Altucci, Lucia ;

Jansen, Joop H. ;

Walter, Joern ;

Gut, Ivo G. ;

Marks, Hendrik ;

Stunnenberg, Hendrik G. .

CELL STEM CELL, 2013, 13 (03) :360-369

[9]

Persistent epigenetic differences associated with prenatal exposure to famine in humans [J].

Heijmans, Bastiaan T. ;

Tobi, Elmar W. ;

Stein, Aryeh D. ;

Putter, Hein ;

Blauw, Gerard J. ;

Susser, Ezra S. ;

Slagboom, P. Eline ;

Lumey, L. H. .

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 2008, 105 (44) :17046-17049

[10]

First evidence for an association of a functional variant in the microRNA-510 target site of the serotonin receptor-type 3E gene with diarrhea predominant irritable bowel syndrome [J].

Kapeller, Johannes ;

Houghton, Lesley A. ;

Moennikes, Hubert ;

Walstab, Jutta ;

Moeller, Dorothee ;

Boenisch, Heinz ;

Burwinkel, Barbara ;

Autschbach, Frank ;

Funke, Benjamin ;

Lasitschka, Felix ;

Gassler, Nikolaus ;

Fischer, Christine ;

Whorwell, Peter J. ;

Atkinson, Wendy ;

Fell, Catherine ;

Buechner, Karl J. ;

Schmidtmann, Marco ;

van der Voort, Ivo ;

Wisser, Anna-Sophia ;

Berg, Thomas ;

Rappold, Gudrun ;

Niesler, Beate .

HUMAN MOLECULAR GENETICS, 2008, 17 (19) :2967-2977

← 1 2 →