Transcranial magnetic stimulation potentiates glutamatergic neurotransmission in depressed adolescents

被引：54

作者：

Croarkin, Paul E. ^{[1
]}

Nakonezny, Paul A. ^{[2
]}

Wall, Christopher A. ^{[3
]}

Murphy, Lauren L. ^{[1
]}

Sampson, Shirlene M. ^{[1
]}

Frye, Mark A. ^{[1
]}

Port, John D. ^{[1
,4
]}

机构：

[1] Mayo Clin, Dept Psychiat & Psychol, Rochester, MN 55905 USA

[2] UT Southwestern Med Ctr, Div Biostat, Dept Clin Sci, Dallas, TX USA

[3] PrairieCare, Rochester, MN USA

[4] Mayo Clin, Dept Radiol, Rochester, MN 55905 USA

来源：

PSYCHIATRY RESEARCH-NEUROIMAGING | 2016年 / 247卷

关键词：

Adolescent depression; Glutamate; Glutamine; Proton magnetic resonance spectroscopy; Repetitive transcranial magnetic stimulation; RESONANCE-SPECTROSCOPY; MAJOR DEPRESSION; METABOLIC ALTERATIONS; PREFRONTAL CORTEX; BRAIN; DISORDER; RTMS; SCHIZOPHRENIA; RELIABILITY; SAFETY;

D O I：

10.1016/j.pscychresns.2015.11.005

中图分类号：

R74 [神经病学与精神病学];

学科分类号：

100204 [神经病学];

摘要：

Abnormalities in glutamate neurotransmission may have a role in the pathophysiology of adolescent depression. The present pilot study examined changes in cortical glutamine/glutamate ratios in depressed adolescents receiving high-frequency repetitive transcranial magnetic stimulation. Ten adolescents with treatment-refractory major depressive disorder received up to 30 sessions of 10-Hz repetitive transcranial magnetic stimulation at 120% motor threshold with 3000 pulses per session applied to the left dorsolateral prefrontal cortex. Baseline, posttreatment, and 6-month follow-up proton magnetic resonance spectroscopy scans of the anterior cingulate cortex and left dorsolateral prefrontal cortex were collected at 3 T with 8-cm(3) voxels. Glutamate metabolites were quantified with 2 distinct proton magnetic resonance spectroscopy sequences in each brain region. After repetitive transcranial magnetic stimulation and at 6 months of follow-up, glutamine/glutamate ratios increased in the anterior cingulate cortex and left dorsolateral prefrontal cortex with both measurements. The increase in the glutamine/ glutamate ratio reached statistical significance with the TE-optimized PRESS sequence in the anterior cingulate cortex. Glutamine/glutamate ratios increased in conjunction with depressive symptom improvement. This reached statistical significance with the TE-optimized PRESS sequence in the left dorsolateral prefrontal cortex. High-frequency repetitive transcranial magnetic stimulation applied to the left dorsolateral prefrontal cortex may modulate glutamate neurochemistry in depressed adolescents. (C) 2015 Elsevier Ireland Ltd. All rights reserved.

引用

页码：25 / 33

页数：9

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