Regioselective synthesis of various prodrugs of ganciclovir

被引：10

作者：

Gao, HW ^{[1
]}

Mitra, AK ^{[1
]}

机构：

[1] Univ Missouri, Sch Pharm, Div Pharmaceut Sci, Kansas City, MO 64100 USA

来源：

TETRAHEDRON LETTERS | 2000年 / 41卷 / 08期

基金：

美国国家卫生研究院;

关键词：

D O I：

10.1016/S0040-4039(99)02280-7

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

High-yield regioselective syntheses of 9-[(1,3-dihydroxy-2-propoxy)methyl]guanine mono-, di- and tri-substitution derivatives as potential prodrugs were accomplished via one or multisteps. Two amino acid esters of ganciclovir were synthesized as water-soluble prodrugs, which form protonated cations in pH 7.4 phosphate buffer. (C) 2000 Elsevier Science Ltd. All rights reserved.

引用

页码：1131 / 1136

页数：6

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