Synthesis of reactive gamma-lactams related to penicillins and cephalosporins

被引：12

作者：

Davies, GM

Hitchcock, PB

Loakes, D

Young, DW

机构：

[1] ZENECA PHARMACEUT,MACCLESFIELD SK10 4TG,CHESHIRE,ENGLAND

[2] UNIV SUSSEX,SCH CHEM & MOL SCI,BRIGHTON BN1 9QJ,E SUSSEX,ENGLAND

来源：

TETRAHEDRON LETTERS | 1996年 / 37卷 / 31期

关键词：

D O I：

10.1016/0040-4039(96)01135-5

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

Gamma lactam analogues based on the penicillin and cephalosporin framework have been synthesised which, in keeping with their design as potential inhibitors of bacterial cell wall biosynthesis, show high reactivity towards modest nucleophiles. An X-ray crystal structure of one of these compounds allows structural comparisons to be made with classical beta-lactam antibiotics. Copyright (C) 1996 Elsevier Science Ltd

引用

页码：5601 / 5604

页数：4

共 21 条

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