HP1 controls telomere capping, telomere elongation, and telomere silencing by two different mechanisms in Drosophila

被引：134

作者：

Perrini, B

Piacentini, L

Fanti, L

Altieri, F

Chichiarelli, S

Berloco, M

Turano, C

Ferraro, A

Pimpinelli, S ^{[1
]}

机构：

[1] Univ Roma La Sapienza, Fdn Cenci Bolognetti, I-00185 Rome, Italy

[2] Univ Roma La Sapienza, Dipartimento Genet & Biol Mol, I-00185 Rome, Italy

[3] Univ Roma La Sapienza, Dipartimento Sci Biochim, Ist Pasteur, I-00185 Rome, Italy

[4] Univ Bari, Dipartimento Genet & Anat Patol, I-00165 Bari, Italy

来源：

MOLECULAR CELL | 2004年 / 15卷 / 03期

关键词：

D O I：

10.1016/j.molcel.2004.06.036

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

HP1 is a conserved chromosomal protein, first discovered in Drosophila, which is predominantly associated with the heterochromatin of many organisms. Recently, it has been shown that HP1 is required for telomere capping, telomere elongation, and transcriptional repression of telomeric sequences. Several studies have suggested a model for heterochromatin formation and epigenetic gene silencing in different species that is based on interactions among histone methyltransferases (HMTases), histone H3 methylated at lysine 9 (H3-MeK9), and the HP1 chromodomain. This model has been extended to HP1 telomeric localization by data showing that H3-MeK9 is present at all of the telomeres. Here, we tested this model, and we found that the capping function of HP1 is due to its direct binding to telomeric DNA, while the silencing of telomeric sequences and telomere elongation is due to its interaction with H3-MeK9.

引用

页码：467 / 476

页数：10

共 65 条

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