Modules, networks and systems medicine for understanding disease and aiding diagnosis

被引:125
作者
Gustafsson, Mika [1 ]
Nestor, Colm E. [1 ]
Zhang, Huan [1 ]
Barabasi, Albert-Laszlo [2 ]
Baranzini, Sergio [3 ]
Brunak, Soeren [4 ,5 ]
Chung, Kian Fan [6 ]
Federoff, Howard J. [7 ]
Gavin, Anne-Claude [8 ]
Meehan, Richard R. [9 ]
Picotti, Paola [10 ]
Pujana, Miguel Angel [11 ]
Rajewsky, Nikolaus [12 ]
Smith, Kenneth G. C. [13 ,14 ]
Sterk, Peter J. [15 ]
Villoslada, Pablo [16 ,17 ]
Benson, Mikael [1 ]
机构
[1] Ctr Individualized Med, Dept Pediat, Fac Med, S-58185 Linkoping, Sweden
[2] Northeastern Univ, Ctr Complex Network Res, Dept Phys Biol & Comp Sci, Boston, MA 02115 USA
[3] Univ Calif San Francisco, Dept Neurol, San Francisco, CA 94143 USA
[4] Tech Univ Denmark, Dept Syst Biol, Ctr Biol Sequence Anal, DK-2800 Lyngby, Denmark
[5] Univ Copenhagen, Fac Hlth Sci, Novo Nordisk Fdn Ctr Prot Res, DK-2200 Copenhagen, Denmark
[6] Univ London Imperial Coll Sci Technol & Med, Natl Heart & Lung Inst, Airways Dis Sect, London SW3 6LY, England
[7] Georgetown Univ, Med Ctr, Dept Neurol & Neurosci, Washington, DC 20057 USA
[8] European Mol Biol Lab, D-69117 Heidelberg, Germany
[9] Univ Edinburgh, MRC IGMM, MRC Human Genet Unit, Edinburgh EH4 2XU, Midlothian, Scotland
[10] Univ Zurich, Inst Biochem, CH-8093 Zurich, Switzerland
[11] Bellvitge Biomed Res Inst IDIBELL, Catalan Inst Oncol, Barcelona 08908, Spain
[12] Max Delbruck Ctr Mol Med, D-13125 Berlin, Germany
[13] Univ Cambridge, Cambridge Inst Med Res, Cambridge CB2 0XY, England
[14] Univ Cambridge, Addenbrookes Hosp, Sch Clin Med, Dept Med, Cambridge CB2 0QQ, England
[15] Univ Amsterdam, Acad Med Ctr, Dept Resp Med, NL-1100 DE Amsterdam, Netherlands
[16] Hosp Clin Barcelona, Ctr Neuroimmunol, E-08028 Barcelona, Spain
[17] Hosp Clin Barcelona, Inst Invest Biomed August Pi & Sunyer IDIBAP, Dept Neurol, E-08028 Barcelona, Spain
来源
GENOME MEDICINE | 2014年 / 6卷
基金
英国生物技术与生命科学研究理事会; 英国医学研究理事会;
关键词
BIOMARKER DISCOVERY; BIOLOGY APPROACH; CANCER; SUSCEPTIBILITY; TRANSCRIPTOME; EMERGENCE; EVOLUTION;
D O I
10.1186/s13073-014-0082-6
中图分类号
Q3 [遗传学];
学科分类号
071007 ; 090102 ;
摘要
Many common diseases, such as asthma, diabetes or obesity, involve altered interactions between thousands of genes. High-throughput techniques (omics) allow identification of such genes and their products, but functional understanding is a formidable challenge. Network-based analyses of omics data have identified modules of disease-associated genes that have been used to obtain both a systems level and a molecular understanding of disease mechanisms. For example, in allergy a module was used to find a novel candidate gene that was validated by functional and clinical studies. Such analyses play important roles in systems medicine. This is an emerging discipline that aims to gain a translational understanding of the complex mechanisms underlying common diseases. In this review, we will explain and provide examples of how network-based analyses of omics data, in combination with functional and clinical studies, are aiding our understanding of disease, as well as helping to prioritize diagnostic markers or therapeutic candidate genes. Such analyses involve significant problems and limitations, which will be discussed. We also highlight the steps needed for clinical implementation.
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页数:11
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