Multiple cholesterol-phospholipid complexes in membranes

被引:6
作者
Anderson, TG [1 ]
McConnell, HM [1 ]
机构
[1] Stanford Univ, Dept Chem, Stanford, CA 94305 USA
基金
美国国家卫生研究院;
关键词
phase equilibrium; cooperativity; monolayers; chemical reactions; complexes;
D O I
10.1016/S0927-7757(99)00554-3
中图分类号
O64 [物理化学(理论化学)、化学物理学];
学科分类号
070304 ; 081704 ;
摘要
Previous work has implied the formation of 'condensed complexes' of cholesterol and phospholipids in monolayers at the air-water interface. The present study gives illustrative theoretical calculations of phase diagrams, concentration profiles, and average molecular areas when more than one complex is assumed to be present. It is shown that multiple complexes should be detectable experimentally under some but not all conditions. The relationship between condensed complexes in monolayers and bilayers is discussed. (C) 2000 Elsevier Science B.V. All rights reserved.
引用
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页码:13 / 23
页数:11
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