InAs(ZnCdS) Quantum Dots Optimized for Biological Imaging in the Near-Infrared

被引：167

作者：

Allen, Peter M. ^{[1
]}

Liu, Wenhao ^{[1
]}

Chauhan, Vikash P. ^{[2
,3
]}

Lee, Jungmin ^{[1
]}

Ting, Alice Y. ^{[1
]}

Fukumura, Dai ^{[2
,3
]}

Jain, Rakesh K. ^{[2
,3
]}

Bawendi, Moungi G. ^{[1
]}

机构：

[1] MIT, Dept Chem, Cambridge, MA 02139 USA

[2] Massachusetts Gen Hosp, Dept Radiat Oncol, Edwin L Steele Lab, Boston, MA 02114 USA

[3] Harvard Univ, Sch Med, Boston, MA 02114 USA

来源：

JOURNAL OF THE AMERICAN CHEMICAL SOCIETY | 2010年 / 132卷 / 02期

基金：

美国国家科学基金会;

关键词：

CORE-SHELL NANOCRYSTALS; IN-VIVO; BIOTIN LIGASE; LIVING CELLS; SIZE SERIES; MONOVALENT; PROTEINS;

D O I：

10.1021/ja908250r

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

We present the synthesis of InAs quantum dots (QDs) with a ZnCdS shell with bright and stable emission in the near-infrared (NIR, 700-900 nm) region for biological imaging applications, We demonstrate how NIR QDs can image tumor vasculature in vivo at significantly deeper penetration depths and with higher contrast than visible emitting CdSe(CdS) QDs. Targeted cellular labeling is also presented and may enable multiplexed and low auto fluorescence cellular imaging.

引用

收藏

页码：470 / +

页数：4

相关论文

共 15 条

[1] Synthesis of InAs/CdSe/ZnSe core/shell1/shell2 structures with bright and stable near-infrared fluorescence [J].

Aharoni, A ;

Mokari, T ;

Popov, I ;

Banin, U .

JOURNAL OF THE AMERICAN CHEMICAL SOCIETY, 2006, 128 (01) :257-264

[2] In vivo measurement of gene expression, angiogenesis and physiological function in tumors using multiphoton laser scanning microscopy [J].

Brown, EB ;

Campbell, RB ;

Tsuzuki, Y ;

Xu, L ;

Carmeliet, P ;

Fukumura, D ;

Jain, RK .

NATURE MEDICINE, 2001, 7 (07) :864-868

[3] Growth and properties of semiconductor core/shell nanocrystals with InAs cores [J].

Cao, YW ;

Banin, U .

JOURNAL OF THE AMERICAN CHEMICAL SOCIETY, 2000, 122 (40) :9692-9702

[4] Tissue- and Organ-Selective Biodistribution of NIR Fluorescent Quantum Dots [J].

Choi, Hak Soo ;

Ipe, Binil Itty ;

Misra, Preeti ;

Lee, Jeong Heon ;

Bawendi, Moungi G. ;

Frangioni, John V. .

NANO LETTERS, 2009, 9 (06) :2354-2359

[5] (CdSe)ZnS core-shell quantum dots: Synthesis and characterization of a size series of highly luminescent nanocrystallites [J].

Dabbousi, BO ;

RodriguezViejo, J ;

Mikulec, FV ;

Heine, JR ;

Mattoussi, H ;

Ober, R ;

Jensen, KF ;

Bawendi, MG .

JOURNAL OF PHYSICAL CHEMISTRY B, 1997, 101 (46) :9463-9475

[6] Targeting quantum dots to surface proteins in living cells with biotin ligase [J].

Howarth, M ;

Takao, K ;

Hayashi, Y ;

Ting, AY .

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 2005, 102 (21) :7583-7588

[7] Imaging proteins in live mammalian cells with biotin ligase and monovalent streptavidin [J].

Howarth, Mark ;

Ting, Alice Y. .

NATURE PROTOCOLS, 2008, 3 (03) :534-545

[8] Monovalent, reduced-size quantum dots for imaging receptors on living cells [J].

Howarth, Mark ;

Liu, Wenhao ;

Puthenveetil, Sujiet ;

Zheng, Yi ;

Marshall, Lisa F. ;

Schmidt, Michael M. ;

Wittrup, K. Dane ;

Bawendi, Moungi G. ;

Ting, Alice Y. .

NATURE METHODS, 2008, 5 (05) :397-399

[9] Near-infrared fluorescent type II quantum dots for sentinel lymph node mapping [J].

Kim, S ;

Lim, YT ;

Soltesz, EG ;

De Grand, AM ;

Lee, J ;

Nakayama, A ;

Parker, JA ;

Mihaljevic, T ;

Laurence, RG ;

Dor, DM ;

Cohn, LH ;

Bawendi, MG ;

Frangioni, JV .

NATURE BIOTECHNOLOGY, 2004, 22 (01) :93-97

[10]

Lide DavidR., 2003, Handbook of Chemistry and Physics, V84th