Age related changes of human aortic distensibility: evaluation with ECG-gated CT

被引:54
作者
Ganten, Marika
Krautter, Ute
Hosch, Waldemar
Hansmann, Jochen
von Tengg-Kobligk, Hendrik
Delorme, Stefan
Kauczor, Hans-Ulrich
Kauffmann, Guenter W.
Bock, Michael
机构
[1] Univ Heidelberg, Radiol Univ Hosp, Dept Diagnost Radiol, D-69120 Heidelberg, Germany
[2] Deutsch Krebsforschungszentrum, Dept Biophys & Med Radiat Phys, D-69120 Heidelberg, Germany
关键词
MDCT; ECG gating; aorta; arterial wall motion; elasticity;
D O I
10.1007/s00330-006-0309-z
中图分类号
R8 [特种医学]; R445 [影像诊断学];
学科分类号
1002 [临床医学]; 100207 [影像医学与核医学]; 1009 [特种医学];
摘要
Aortic distensibility is a parameter to grade vascular diseases and age-related effects because it is related to the elastic properties of the vessel wall. In this study vascular cross-sectional area changes have been determined using ECG-gated CT to analyse the age dependency of aortic distensibility. Distensibility measurements of the aorta were performed in 31 subjects (28 to 85 years). Time-resolved images were acquired either with a 4- or 16-detector row CT system using a modified CT angiography protocol. Cross-sectional area changes of the aorta were calculated by semiautomatic segmentation, and distensibility values were obtained using additional systemic blood pressure measurements. The aorta could be segmented successfully in all subjects. A decrease of aortic distensibility with age was found (r=0.50). Below (above) the renal arteries, the annual decrease was Delta D (infrarenal) =(- 2.1 +/- 0.7).10(-7)Pa(-1) a(-1), (D (suprarenal) Delta=(-3.5 +/- 1.1).10(-7) Pa-1 a(-1)). Differences between the ages, the youngest third and oldest third studied, were found to be significant ( (suprarenal)=0.003; P (infrarenal) =0.025). An age-dependent decrease of aortic wall elasticity can be determined in a modified routine CT angiography study.
引用
收藏
页码:701 / 708
页数:8
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