Assaying hematopoiesis using zebrafish

被引：32

作者：

Boatman, Sonja ^{[1
,2
]}

Barrett, Francesca ^{[1
,2
]}

Satishchandran, Sruthi ^{[1
,2
]}

Jing, Lili ^{[1
,2
]}

Shestopalov, Ilya ^{[1
,2
]}

Zon, Leonard I. ^{[1
,2
,3
]}

机构：

[1] Harvard Univ, Sch Med, Childrens Hosp Boston, Stem Cell Program, Boston, MA 02114 USA

[2] Harvard Univ, Sch Med, Childrens Hosp Boston, Div Hematol Oncol, Boston, MA USA

[3] Howard Hughes Med Inst, Chevy Chase, MD USA

来源：

BLOOD CELLS MOLECULES AND DISEASES | 2013年 / 51卷 / 04期

关键词：

Zebrafish; Hematopoiesis; Stem cell; Screens; Transplantation; CELL TRANSPLANTATION; ADULT HEMATOPOIESIS; GENETIC SCREEN; TIF1-GAMMA; PROSTAGLANDIN-E2; SPECIFICATION; ELONGATION; MIGRATION; PARADIGM; MUTANTS;

D O I：

10.1016/j.bcmd.2013.07.009

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

The zebrafish has become a commonly used model for studying hematopoiesis as a result of its unique attributes. Zebrafish are highly suitable for large-scale genetic and chemical screens compared to other vertebrate systems. It is now possible to analyze hematopoietic lineages in zebrafish and validate cell function via transplantation assays. Here, we review advancements over the past decade in forward genetic screens, chemical screens, fluorescence-activated cell sorting analysis, and transplantation assays. Integrating these approaches enables new chemical and genetic screens that assay cell function within the hematopoietic system. Studies in zebrafish will continue to contribute and expand our knowledge about hematopoiesis, and develop novel treatments for clinical applications. (C) 2013 Elsevier Inc. All rights reserved.

引用

页码：271 / 276

页数：6

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