The AcrAB-TolC efflux pump contributes to multidrug resistance in the nosocomial pathogen Enterobacter aerogenes

被引：132

作者：

Pradel, E ^{[1
]}

Pagès, JM ^{[1
]}

机构：

[1] Fac Med, INSERM, CJF9606 EA2197, IFR48, F-13385 Marseille 05, France

来源：

ANTIMICROBIAL AGENTS AND CHEMOTHERAPY | 2002年 / 46卷 / 08期

关键词：

D O I：

10.1128/AAC.46.8.2640-2643.2002

中图分类号：

Q93 [微生物学];

学科分类号：

071005 ; 100705 ;

摘要：

We identified the genes encoding the AcrA-AcrB-TolC efflux pump in Enterobacter aerogenes and constructed acrAB and tolC mutants from a multidrug-resistant isolate. Both derivatives were more susceptible to antibiotics than the parental strain. Sequence analysis and complementation experiments revealed that the multidrug-resistant isolate is an acrR mutant.

引用

页码：2640 / 2643

页数：4