Signal transduction and co-stimulatory pathways

被引:18
作者
Kiefer, F
Vogel, WF
Arnold, R
机构
[1] WG Kerckhoff Inst, Max Planck Inst Physiol & Clin Res, D-61231 Bad Nauheim, Germany
[2] Univ Toronto, Dept Lab Med & Pathobiol, Toronto, ON M5S 1A8, Canada
关键词
signal transduction; immunoreceptors; immunological synapse; co-stimulatory pathways; HPK1;
D O I
10.1016/S0966-3274(02)00009-6
中图分类号
R392 [医学免疫学]; Q939.91 [免疫学];
学科分类号
100102 ;
摘要
Using specific cell surface receptors lymphocytes continuously sample their environment. Maturation of the immune system and initiation of a specific immune response rely on an array of extracellular cues that elicit complex intracellular biochemical signals. Essential molecules involved in signal transduction from immunoreceptors have emerged. After immunoreceptor engagement a core signaling complex is assembled comprising cytoplasmic immunoreceptor chains, kinases of the Sre and ZAP70 families and various cytoplasmic and transmembrane adaptor molecules. Further effectors nucleate onto this complex evoking the characteristic responses of lymphocyte activation. Successful maturation of T cells into effector cells relies on the presence of a persistent stimulus presented in an appropriate extracellular environment. Encounter of MHC presented antigenic peptides and their cognate T cell receptors (TCRs) results in the formation of a nanometer intercellular gap between T cells and antigen presenting cells, which is now commonly referred to as the immunological synapse. The synapse is believed to sustain persistent TCR engagement. Its formation requires massive changes in T cell cytoskeletal architecture which essentially relies on signals provided by costimulatory molecules. The well orchestrated interplay between TCR and costimulatory signals decides about successful immune response and tolerance induction or immune failure and autoimmunity. (C) 2002 Elsevier Science B.V. All rights reserved.
引用
收藏
页码:69 / 82
页数:14
相关论文
共 53 条
[41]   Hematopoietic progenitor kinase 1 associates physically and functionally with the adaptor proteins B cell linker protein and SLP-76 in lymphocytes [J].
Sauer, K ;
Liou, J ;
Singh, SB ;
Yablonski, D ;
Weiss, A ;
Perlmutter, RM .
JOURNAL OF BIOLOGICAL CHEMISTRY, 2001, 276 (48) :45207-45216
[42]   Apoptosis signaling in lymphocytes [J].
Scaffidi, C ;
Kirchhoff, S ;
Krammer, PH ;
Peter, ME .
CURRENT OPINION IN IMMUNOLOGY, 1999, 11 (03) :277-285
[43]   Cell Signaling by Receptor Tyrosine Kinases [J].
Lemmon, Mark A. ;
Schlessinger, Joseph .
CELL, 2010, 141 (07) :1117-1134
[44]   The role of NF-AT transcription factors in T cell activation and differentiation [J].
Serfling, E ;
Berberich-Siebelt, F ;
Chuvpilo, S ;
Jankevics, E ;
Klein-Hessling, S ;
Twardzik, T ;
Avots, A .
BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR CELL RESEARCH, 2000, 1498 (01) :1-18
[45]   B cell adaptor containing Src homology 2 domain (BASH) links B cell receptor signaling to the activation of hematopoietic progenitor kinase 1 [J].
Tsuji, S ;
Okamoto, M ;
Yamada, K ;
Okamoto, N ;
Goitsuka, R ;
Arnold, R ;
Kiefer, F ;
Kitamura, D .
JOURNAL OF EXPERIMENTAL MEDICINE, 2001, 194 (04) :529-539
[46]   Tyrosine kinase SYK: essential functions for immunoreceptor signalling [J].
Turner, M ;
Schweighoffer, E ;
Colucci, F ;
Di Santo, JP ;
Tybulewicz, VL .
IMMUNOLOGY TODAY, 2000, 21 (03) :148-154
[47]  
Vogel WF, 2001, EUR J DERMATOL, V11, P506
[48]   Phosphoinositide 3-kinases in T lymphocyte activation [J].
Ward, SG ;
Cantrell, DA .
CURRENT OPINION IN IMMUNOLOGY, 2001, 13 (03) :332-338
[49]   Switching signals on or off by receptor dimerization [J].
Weiss, A ;
Schlessinger, J .
CELL, 1998, 94 (03) :277-280
[50]   The transmembrane adapter LAT plays a central role in immune receptor signalling [J].
Wonerow, P ;
Watson, SP .
ONCOGENE, 2001, 20 (44) :6273-6283