Dendritic protein synthesis, synaptic plasticity, and memory

被引：670

作者：

Sutton, Michael A. ^{[1
]}

Schuman, Erin M. ^{[1
]}

机构：

[1] CALTECH, Howard Hughes Med Inst, Div Biol 114 96, Pasadena, CA 91125 USA

来源：

CELL | 2006年 / 127卷 / 01期

关键词：

D O I：

10.1016/j.cell.2006.09.014

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Considerable evidence suggests that the formation of long-term memories requires a critical period of new protein synthesis. Recently, the notion that some of these newly synthesized proteins originate through local translation in neuronal dendrites has gained some traction. Here, we review the experimental support for this idea and highlight some of the key questions outstanding in this area.

引用

页码：49 / 58

页数：10

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