Rh-catalysed asymmetric hydrogenations with a dynamic library of chiral tropos phosphorus-ligands

被引：37

作者：

Monti, C

Gennari, C

Piarulli, U

机构：

[1] Univ Milan, Dipartimento Chim Organ & Ind, Ctr Eccellenza CISI, CNR,ISTM, I-20133 Milan, Italy

[2] Univ Insubria, Dipartimento Sci Chim & Ambientali, I-22100 Como, Italy

来源：

TETRAHEDRON LETTERS | 2004年 / 45卷 / 37期

关键词：

enantioselective catalysis; asymmetric hydrogenation; rhodium; phosphites; phosphoramidites;

D O I：

10.1016/j.tetlet.2004.07.100

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

A library of 16 chiral tropos phosphorus-ligands, based on a chiral P-bound alcohol or secondary amine and a flexible (tropos) P-bound biphenol unit, was synthesised. This ligand library allowed the screening of 16 homocombinations and 115 heterocombinations for the rhodium catalysed asymmetric hydrogenation of methyl N-acetamido acrylate. The screening resulted in the identification of a phosphite/phosphoramidite heterocombination, which proved to be extremely effective and enantio selective (100% yield, 94% ee). (C) 2004 Elsevier Ltd. All rights reserved.

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页码：6859 / 6862

页数：4

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