Robotic plasma probe ionization mass spectrometry (RoPPI-MS) of non-planar surfaces

被引:14
作者
Bennett, Rachel V. [1 ]
Morzan, Ezequiel M. [1 ]
Huckaby, Jacob O. [2 ]
Monge, Maria Eugenia [1 ]
Christensen, Henrick I. [2 ]
Fernandez, Facundo M. [1 ]
机构
[1] Georgia Inst Technol, Sch Chem & Biochem, Atlanta, GA 30332 USA
[2] Georgia Inst Technol, Inst Robot & Intelligent Machines, Atlanta, GA 30332 USA
基金
美国国家科学基金会;
关键词
INDUCED CHEMICAL-IONIZATION; AMBIENT CONDITIONS; MOUSE-BRAIN; ION-SOURCE; OPEN-AIR; TISSUE; METABOLITES;
D O I
10.1039/c4an00277f
中图分类号
O65 [分析化学];
学科分类号
070302 ; 081704 ;
摘要
In this report, we present a robotic sample introduction/ionization system for mass spectrometry (MS) for spot analysis and imaging of non-planar surfaces. The system operates by probing the sample surface with an acupuncture needle, followed by direct plasma chemical ionization time-of-flight MS.
引用
收藏
页码:2658 / 2662
页数:5
相关论文
共 20 条
[1]  
[Anonymous], 1981, CRC Handbook of Chemistry and Physics, pD
[2]   Molecular imaging of biological samples: Localization of peptides and proteins using MALDI-TOF MS [J].
Caprioli, RM ;
Farmer, TB ;
Gile, J .
ANALYTICAL CHEMISTRY, 1997, 69 (23) :4751-4760
[3]   Ambient imaging mass spectrometry by electrospray ionization using solid needle as sampling probe [J].
Chen, Lee Chuin ;
Yoshimura, Kentaro ;
Yu, Zhan ;
Iwata, Rikiya ;
Ito, Hajime ;
Suzuki, Hiroaki ;
Mori, Kunihiko ;
Ariyada, Osamu ;
Takeda, Sen ;
Kubota, Takeo ;
Hiraoka, Kenzo .
JOURNAL OF MASS SPECTROMETRY, 2009, 44 (10) :1469-1477
[4]   Versatile new ion source for the analysis of materials in open air under ambient conditions [J].
Cody, RB ;
Laramée, JA ;
Durst, HD .
ANALYTICAL CHEMISTRY, 2005, 77 (08) :2297-2302
[5]   Observation of Molecular Ions and Analysis of Nonpolar Compounds with the Direct Analysis in Real Time Ion Source [J].
Cody, Robert B. .
ANALYTICAL CHEMISTRY, 2009, 81 (03) :1101-1107
[6]   Three-dimensional visualization of protein expression in mouse brain structures using imaging mass spectrometry [J].
Crecelius, AC ;
Cornett, DS ;
Caprioli, RM ;
Williams, B ;
Dawant, BM ;
Bodenheimer, B .
JOURNAL OF THE AMERICAN SOCIETY FOR MASS SPECTROMETRY, 2005, 16 (07) :1093-1099
[7]   Three-Dimensional Vizualization of Mouse Brain by Lipid Analysis Using Ambient Ionization Mass Spectrometry [J].
Eberlin, Livia S. ;
Ifa, Demian R. ;
Wu, Chunping ;
Cooks, R. Graham .
ANGEWANDTE CHEMIE-INTERNATIONAL EDITION, 2010, 49 (05) :873-876
[8]   TOF-SIMS 3D biomolecular imaging of Xenopus laevis oocytes using buckminsterfullerene (C60) primary ions [J].
Fletcher, John S. ;
Lockyer, Nicholas P. ;
Vaidyanathan, Seetharaman ;
Vickerman, John C. .
ANALYTICAL CHEMISTRY, 2007, 79 (06) :2199-2206
[9]   Small Molecule Ambient Mass Spectrometry Imaging by Infrared Laser Ablation Metastable-Induced Chemical Ionization [J].
Galhena, Asiri S. ;
Harris, Glenn A. ;
Nyadong, Leonard ;
Murray, Kermit K. ;
Fernandez, Facundo M. .
ANALYTICAL CHEMISTRY, 2010, 82 (06) :2178-2181
[10]   Simulations and Experimental Investigation of Atmospheric Transport in an Ambient Metastable-Induced Chemical Ionization Source [J].
Harris, Glenn A. ;
Fernandez, Facundo M. .
ANALYTICAL CHEMISTRY, 2009, 81 (01) :322-329