Raf-like Ras/Rap-binding domains in RGS12-and still-life-like signalling proteins

被引:49
作者
Ponting, CP [1 ]
机构
[1] NIH, Natl Lib Med, Natl Ctr Biotechnol Informat, Bethesda, MD 20814 USA
来源
JOURNAL OF MOLECULAR MEDICINE-JMM | 1999年 / 77卷 / 10期
关键词
regulator of G protein signalling; LGN motifs; G(i)alpha GTPase; Tiam-1; signalling pathway;
D O I
10.1007/s001099900054
中图分类号
Q3 [遗传学];
学科分类号
071007 ; 090102 ;
摘要
Ras proteins play critical roles in regulating cell growth and differentiation, and mutated Ras genes are expressed in a variety of human cancers. Consequently, much interest has centered on the binding partners of Ras, including the Ras-binding domain (RBD) of Raf kinase. Here evidence is presented that domains homologous to the Raf RED are present in tandem in RGS12, RGS14 and LOGO, and singly in molecules similar to mouse Tiam-1. In addition; RGS12, RGS14 and LOCO are shown to contain single "LGN motifs" that are guanine nucleotide exchange factors specific for the cc-subunit of G proteins. These findings indicate "cross-talk" interactions between signalling pathways involving Ras and Rap and pathways involving Rho, Rac and Ga GTPases.
引用
收藏
页码:695 / 698
页数:4
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