TRANSPATH®:: an information resource for storing and visualizing signaling pathways and their pathological aberrations

被引:104
作者
Krull, Mathias
Pistor, Susanne
Voss, Nico
Kel, Alexander
Reuter, Ingmar
Kronenberg, Deborah
Michael, Holger
Schwarzer, Knut
Potapov, Anatolij
Choi, Claudia
Kel-Margoulis, Olga
Wingender, Edgar
机构
[1] BIOBASE GmbH, D-38304 Wolfenbuttel, Germany
[2] Univ Gottingen, Dept Bioinformat, Sch Med, D-37077 Gottingen, Germany
关键词
D O I
10.1093/nar/gkj107
中图分类号
Q5 [生物化学]; Q7 [分子生物学];
学科分类号
071010 ; 081704 ;
摘要
TRANSPATH (R) is a database about signal transduction events. It provides information about signaling molecules, their reactions and the pathways these reactions constitute. The representation of signaling molecules is organized in a number of orthogonal hierarchies reflecting the classification of the molecules, their species-specific or generic features, and their post-translational modifications. Reactions are similarly hierarchically organized in a three-layer architecture, differentiating between reactions that are evidenced by individual publications, generalizations of these reactions to construct species-independent 'reference pathways' and the 'semantic projections' of these pathways. A number of search and browse options allow easy access to the database contents, which can be visualized with the tool PathwayBuilder (TM). The module PathoSign adds data about pathologically relevant mutations in signaling components, including their genotypes and phenotypes. TRANSPATH (R) and PathoSign can be used as encyclopaedia, in the educational process, for vizualization and modeling of signal transduction networks and for the analysis of gene expression data. TRANSPATH (R) Public 6.0 is freely accessible for users from non-profit organizations under http://www.gene-regulation.com/pub/databases.html.
引用
收藏
页码:D546 / D551
页数:6
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