Diastereoselective cobalt-catalyzed reductive aldol cyclizations using diethylzinc as the stoichiometric reductant

被引：41

作者：

Lam, Hon Wai

Joensuu, Pekka M.

Murray, Gordon J.

Fordyce, Euan A. F.

Prieto, Oscar

Luebbers, Thomas

机构：

[1] Univ Edinburgh, Sch Chem, Edinburgh EH9 3JJ, Midlothian, Scotland

[2] F Hoffmann La Roche & Co Ltd, CH-4070 Basel, Switzerland

来源：

ORGANIC LETTERS | 2006年 / 8卷 / 17期

基金：

英国工程与自然科学研究理事会;

关键词：

D O I：

10.1021/ol061329d

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

Cobalt catalysis enables a new method for the generation of zinc enolates using diethylzinc to reduce alpha,ss-unsaturated amides. This method has been applied to a high-yielding diastereoselective reductive aldol cyclization.

引用

页码：3729 / 3732

页数：4

共 37 条

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