Proteome informatics II: Bioinformatics for comparative proteomics

被引：23

作者：

Lisacek, Frederique

Cohen-Boulakia, Sarah

Appel, Ron D.

机构：

[1] CMU, Swiss Inst Bioinformat, Proteome Informat Grp, CH-1211 Geneva 4, Switzerland

[2] Genom & Informat, Evry, France

[3] Univ Penn, Dept Comp & Informat Sci, Philadelphia, PA 19104 USA

[4] Univ Paris Sud XI, Rech Informat Lab, Paris, France

[5] Univ Geneva, Dept Comp Sci, Geneva, Switzerland

[6] Univ Hosp Geneva, Geneva, Switzerland

来源：

PROTEOMICS | 2006年 / 6卷 / 20期

关键词：

bioinformatics; data integration; ontology; systems biology; Web standards;

D O I：

10.1002/pmic.200600275

中图分类号：

Q5 [生物化学];

学科分类号：

071010 ; 081704 ;

摘要：

The present review attempts to cover the most recent initiatives directed towards representing, storing, displaying and processing protein-related data suited to undertake "comparative proteomics" studies. Data interpretation is brought into focus. Efforts invested into analysing and interpreting experimental data increasingly express the need for adding meaning. This trend is perceptible in work dedicated to determining ontologies, modelling interaction networks, etc. In parallel, technical advances in computer science are spurred by the development of the Web and the growing need to channel and understand massive volumes of data. Biology benefits from these advances as an application of choice for many generic solutions. Some examples of bioinformatics solutions are discussed and directions for on-going and future work conclude the review.

引用

页码：5445 / 5466

页数：22

共 117 条

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