Biotechnology under high pressure: applications and implications

被引：141

作者：

Aertsen, Abram ^{[1
]}

Meersman, Filip ^{[2
]}

Hendrickx, Marc E. G. ^{[1
]}

Vogel, Rudi F. ^{[3
]}

Michiels, Chris W. ^{[1
]}

机构：

[1] Katholieke Univ Leuven, Food Microbiol Lab, Leuven Food Sci & Nutr Res Ctr LFoRCe, Dept Microbial & Mol Syst M2S, B-3001 Louvain, Belgium

[2] Katholieke Univ Leuven, Dept Chem, Div Mol & Nanomat, B-3001 Louvain, Belgium

[3] Tech Univ Munich, Lehrstuhl Tech Mikrobiol, D-85350 Freising Weihenstephan, Germany

来源：

TRENDS IN BIOTECHNOLOGY | 2009年 / 27卷 / 07期

基金：

比利时弗兰德研究基金会;

关键词：

HIGH HYDROSTATIC-PRESSURE; ESCHERICHIA-COLI; PRESSURE/TEMPERATURE TREATMENTS; CATALYTIC-ACTIVITY; AMYLOID FIBRILS; GENE-EXPRESSION; STRESS-RESPONSE; IN-SITU; GROWTH; TEMPERATURE;

D O I：

10.1016/j.tibtech.2009.04.001

中图分类号：

Q81 [生物工程学（生物技术）]; Q93 [微生物学];

学科分类号：

071005 ; 0836 ; 090102 ; 100705 ;

摘要：

Pressure is a thermodynamic parameter whose unique effects on biological systems are increasingly being studied in a growing number of scientific fields. As such, the effects of high pressure are currently being investigated at different levels, ranging from proteins, enzymes and viruses to microorganisms, mammalian cells and tissues. Together with the steadily growing knowledge and understanding of high pressure effects on these increasingly complex systems, the purposeful use of high pressure has found several unique applications in bioscience over the past few years, including the disaggregation of proteins, the preparation of viral vaccines and the modulation of food functionality. In this review, recent and emerging applications of high pressure in biotechnology are presented and discussed.

引用

页码：434 / 441

页数：8

共 96 条

[81] Reconstitution of functional nuclear receptor proteins using high pressure refolding [J].