Copper-catalyzed highly enantioselective 1,4-conjugate addition of trimethylaluminum to 2-cyclohexenone

被引：41

作者：

Liang, L

Chan, ASC ^{[1
]}

机构：

[1] Hong Kong Polytech Univ, Inst Mol Technol Drug Discovery & Synth, Open Lab Chirotechnol, Hong Kong, Hong Kong, Peoples R China

[2] Hong Kong Polytech Univ, Dept Appl Biol & Chem Technol, Hong Kong, Hong Kong, Peoples R China

[3] Guangdong Univ Technol, Fac Chem Engn & Light Ind, Guangzhou, Peoples R China

来源：

TETRAHEDRON-ASYMMETRY | 2002年 / 13卷 / 13期

关键词：

D O I：

10.1016/S0957-4166(02)00361-0

中图分类号：

O61 [无机化学];

学科分类号：

070301 ; 081704 ;

摘要：

New bidentate phosphites were prepared starting from BINOL and H-8-BINOL. Utilization of these ligands in the copper-catalyzed enantioselective conjugate addition of trimethylaluminum to 2-cyclohexenone afforded 3-methylcyclohexanone with up to 96%, e.e. The scope of this process using various copper sources was investigated. (C) 2002 Published by Elsevier Science Ltd.

引用

页码：1393 / 1396

页数：4

共 30 条

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