Naked antigen-presenting molecules on dendritic cells

被引：10

作者：

Davoust, J ^{[1
]}

Banchereau, J ^{[1
]}

机构：

[1] Baylor Inst Immunol Res, Dallas, TX 75204 USA

来源：

NATURE CELL BIOLOGY | 2000年 / 2卷 / 03期

关键词：

D O I：

10.1038/35004075

中图分类号：

Q2 [细胞生物学];

学科分类号：

071009 ; 090102 ;

摘要：

Antigen-presenting cells work to present peptides derived from exogenous and endogenous antigens to circulating T cells, sparking off an immune response. Dendritic cells are unique amongst antigen-presenting cells, not least for their newly described ability to circumvent the need to internalize exogenous antigens before presenting them.

引用

收藏

页码：E46 / E48

页数：3

相关论文

共 14 条

[1] HLA-DM is expressed on the cell surface and colocalizes with HLA-DR and invariant chain in human Langerhans cell [J].

Andersson, T ;

Patwardhan, A ;

Emilson, A ;

Carlsson, K ;

Scheynius, A .

ARCHIVES OF DERMATOLOGICAL RESEARCH, 1998, 290 (12) :674-680

[2] Immunobiology of dendritic cells [J].

Banchereau, J ;

Briere, F ;

Caux, C ;

Davoust, J ;

Lebecque, S ;

Liu, YT ;

Pulendran, B ;

Palucka, K .

ANNUAL REVIEW OF IMMUNOLOGY, 2000, 18 :767-+

[3] Dendritic cells and the control of immunity [J].

Banchereau, J ;

Steinman, RM .

NATURE, 1998, 392 (6673) :245-252

[4] Survival of mature CD4 T lymphocytes is dependent on major histocompatibility complex class II-expressing dendritic cells [J].

Brocker, T .

JOURNAL OF EXPERIMENTAL MEDICINE, 1997, 186 (08) :1223-1232

[5] Invariant chain protects class II histocompatibility antigens from binding intact polypeptides in the endoplasmic reticulum [J].

Busch, R ;

Cloutier, I ;

Sekaly, RP ;

Hammerling, GJ .

EMBO JOURNAL, 1996, 15 (02) :418-428

[6] ASSEMBLY, TRANSPORT, AND FUNCTION OF MHC CLASS-II MOLECULES [J].

CRESSWELL, P .

ANNUAL REVIEW OF IMMUNOLOGY, 1994, 12 :259-293

[7]

Drénou B, 1999, J IMMUNOL, V163, P4115

[8] Detection of empty HLA class II molecules on cord blood B cells [J].

Garban, F ;

Ericson, M ;

Roucard, C ;

RabianHerzog, C ;

Teisserenc, H ;

Sauvanet, E ;

Charron, D ;

Mooney, N .

BLOOD, 1996, 87 (09) :3970-3976

[9] PRODUCTION AND CHARACTERIZATION OF 2 NEW MOUSE MONOCLONAL-ANTIBODIES REACTIVE WITH DENATURED MOUSE CLASS-II BETA-CHAINS [J].

LAPAN, KE ;

KLAPPER, DG ;

FRELINGER, JA .

HYBRIDOMA, 1992, 11 (02) :217-223

[10] Abundant empty class II MHC molecules on the surface of immature dendritic cells [J].

Santambrogio, L ;

Sato, AK ;

Fischer, FR ;

Dorf, ME ;

Stern, LJ .

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 1999, 96 (26) :15050-15055