Heparin-induced thrombocytopenia

被引：70

作者：

Lee, Grace M. ^{[1
]}

Arepally, Gowthami M. ^{[1
]}

机构：

[1] Duke Univ, Med Ctr, Dept Med, Div Hematol, Durham, NC 27710 USA

来源：

HEMATOLOGY-AMERICAN SOCIETY OF HEMATOLOGY EDUCATION PROGRAM | 2013年

基金：

美国国家卫生研究院;

关键词：

OPTICAL-DENSITY; DIAGNOSIS; ANTIBODIES; THROMBOSIS; SCORE; SPECIFICITY; RELEASE; ELISA; STEP;

D O I：

10.1182/asheducation-2013.1.668

中图分类号：

G40 [教育学];

学科分类号：

040101 ; 120403 ;

摘要：

Heparin-induced thrombocytopenia (HIT) is a prothrombotic disorder caused by antibodies that recognize complexes of platelet factor 4 (PF4) and heparin. HIT is frequently considered in the differential diagnosis of thrombocytopenia occurring in patients on heparin therapy. HIT is a challenging diagnosis because of routine heparin use in hospitalized patients, the common occurrence of thrombocytopenia, and high rates of anti-PF4/heparin seroconversions in patients treated with heparin. Our diagnostic approach to HIT is presented here, underscoring critical elements of clinical and laboratory evaluation.

引用

页码：668 / 674

页数：7

共 44 条

[31] Incidence of Thrombocytopenia among Patients Receiving Heparin Venous Thromboembolism Prophylaxis [J].

Wang, Tracy Y. ;

Honeycutt, Emily F. ;

Tapson, Victor F. ;

Moll, Stephan ;

Granger, Christopher B. ;

Ohman, E. Magnus .

AMERICAN JOURNAL OF MEDICINE, 2012, 125 (12) :1214-1221

[32] Laboratory testing for heparin-induced thrombocytopenia: a conceptual framework and implications for diagnosis [J].

Warkentin, T. E. ;

Greinacher, A. ;

Gruel, Y. ;

Aster, R. H. ;

Chong, B. H. .

JOURNAL OF THROMBOSIS AND HAEMOSTASIS, 2011, 9 (12) :2498-2500

[33] Delayed-onset heparin-induced thrombocytopenia and thrombosis [J].

Warkentin, TE ;

Kelton, JG .

ANNALS OF INTERNAL MEDICINE, 2001, 135 (07) :502-506

[34] Temporal aspects of heparin-induced thrombocytopenia [J].

Warkentin, TE ;

Kelton, JG .

NEW ENGLAND JOURNAL OF MEDICINE, 2001, 344 (17) :1286-1292

[35] Laboratory testing for the antibodies that cause heparin-induced thrombocytopenia: How much class do we need? [J].

Warkentin, TE ;

Sheppard, JAI ;

Moore, JC ;

Moore, KM ;

Sigouin, CS ;

Kelton, JG .

JOURNAL OF LABORATORY AND CLINICAL MEDICINE, 2005, 146 (06) :341-346

[36] An improved definition of immune heparin-induced thrombocytopenia in postoperative orthopedic patients [J].

Warkentin, TE ;

Roberts, RS ;

Hirsh, J ;

Kelton, JG .

ARCHIVES OF INTERNAL MEDICINE, 2003, 163 (20) :2518-2524

[37] Heparin-induced thrombocytopenia and cardiac surgery [J].

Warkentin, TE ;

Greinacher, A .

ANNALS OF THORACIC SURGERY, 2003, 76 (02) :638-648

[38] A 14-year study of heparin-induced thrombocytopenia [J].

Warkentin, TE ;

Kelton, JG .

AMERICAN JOURNAL OF MEDICINE, 1996, 101 (05) :502-507

[39]

Warkentin Theodore E, 2006, Hematology Am Soc Hematol Educ Program, P408, DOI 10.1182/asheducation-2006.1.408

[40] Studies of the immune response in heparin-induced thrombocytopenia [J].

Warkentin, Theodore E. ;

Sheppard, Jo-Ann I. ;

Moore, Jane C. ;

Cook, Richard J. ;

Kelton, John G. .

BLOOD, 2009, 113 (20) :4963-4969

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