Physiological role of the endothelin system in human cardiovascular and renal haemodynamics

被引：20

作者：

Webb, D ^{[1
]}

机构：

[1] UNIV EDINBURGH,WESTERN GEN HOSP,RES CTR,EDINBURGH EH4 2XU,MIDLOTHIAN,SCOTLAND

来源：

CURRENT OPINION IN NEPHROLOGY AND HYPERTENSION | 1997年 / 6卷 / 01期

关键词：

D O I：

10.1097/00041552-199701000-00013

中图分类号：

R5 [内科学]; R69 [泌尿科学（泌尿生殖系疾病）];

学科分类号：

1002 ; 100201 ;

摘要：

Based on studies with a number of endothelin antagonists, endothelin-l is now known to play a key physiological role in the maintenance both of basal systemic vascular resistance and of blood pressure in healthy people. Factors that regulate activity of the vascular endothelin system, and its physiological effects on the heart and kidney, now need to be determined.

引用

页码：69 / 73

页数：5

共 46 条

[31] AN ENDOTHELIN-1 MEDIATED AUTOCRINE GROWTH LOOP INVOLVED IN HUMAN RENAL TUBULAR REGENERATION [J].

ONG, ACM ;

JOWETT, TP ;

FIRTH, JD ;

BURTON, S ;

KARET, FE ;

FINE, LG .

KIDNEY INTERNATIONAL, 1995, 48 (02) :390-401

[32] The increase in human plasma immunoreactive endothelin but not big endothelin-1 or its C-terminal fragment induced by systemic administration of the endothelin antagonist TAK-044 [J].

Plumpton, C ;

Ferro, CJ ;

Haynes, WG ;

Webb, DJ ;

Davenport, AP .

BRITISH JOURNAL OF PHARMACOLOGY, 1996, 119 (02) :311-314

[33] PHOSPHORAMIDON INHIBITION OF THE IN-VIVO CONVERSION OF BIG ENDOTHELIN-1 TO ENDOTHELIN-1 IN THE HUMAN FOREARM [J].

PLUMPTON, C ;

HAYNES, WG ;

WEBB, DJ ;

DAVENPORT, AP .

BRITISH JOURNAL OF PHARMACOLOGY, 1995, 116 (02) :1821-1828

[34] Expression of endothelin peptides and mRNA in the human heart [J].

Plumpton, C ;

Ashby, MJ ;

Kuc, RE ;

OReilly, G ;

Davenport, AP .

CLINICAL SCIENCE, 1996, 90 (01) :37-46

[35] INFLUENCE OF SEX-HORMONES ON PLASMA ENDOTHELIN LEVELS [J].

POLDERMAN, KH ;

STEHOUWER, CDA ;

VANKAMP, GJ ;

DEKKER, GA ;

VERHEUGT, FWA ;

GOOREN, LJG .

ANNALS OF INTERNAL MEDICINE, 1993, 118 (06) :429-432

[36] EVIDENCE FOR ENDOTHELIN-INDUCED RENAL VASOCONSTRICTION INDEPENDENT OF ETA RECEPTOR ACTIVATION [J].

POLLOCK, DM ;

OPGENORTH, TJ .

AMERICAN JOURNAL OF PHYSIOLOGY, 1993, 264 (01) :R222-R226

[37] EFFECTS OF ENDOTHELIN-1 ON RENAL-FUNCTION IN HUMANS - IMPLICATIONS FOR PHYSIOLOGY AND PATHOPHYSIOLOGY [J].

RABELINK, TJ ;

KAASJAGER, KAH ;

BOER, P ;

STROES, EG ;

BRAAM, B ;

KOOMANS, HA .

KIDNEY INTERNATIONAL, 1994, 46 (02) :376-381

[38] PLASMA ENDOTHELIN AND RENAL ENDOTHELIN ARE 2 DISTINCT SYSTEMS INVOLVED IN VOLUME HOMEOSTASIS [J].

SERNERI, GGN ;

MODESTI, PA ;

CECIONI, I ;

BIAGINI, D ;

MIGLIORINI, A ;

COSTOLI, A ;

COLELLA, A ;

NALDONI, A ;

PAOLETTI, P .

AMERICAN JOURNAL OF PHYSIOLOGY-HEART AND CIRCULATORY PHYSIOLOGY, 1995, 268 (05) :H1829-H1837

[39] ENDOTHELIN PLAYS A ROLE IN THE MAINTENANCE OF BLOOD-PRESSURE IN NORMOTENSIVE GUINEA-PIGS [J].

VENIANT, M ;

CLOZEL, JP ;

HESS, P ;

CLOZEL, M .

LIFE SCIENCES, 1994, 55 (06) :445-454

[40] EFFECT OF ENDOTHELIN-1 IN MAN [J].

VIERHAPPER, H ;

WAGNER, O ;

NOWOTNY, P ;

WALDHAUSL, W .

CIRCULATION, 1990, 81 (04) :1415-1418

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