International Union of Pharmacology. LXVI. Orphan nuclear receptors

被引：175

作者：

Benoit, Gerard

Cooney, Austin

Giguere, Vincent

Ingraham, Holly

Lazar, Mitch

Muscat, George

Perlmann, Thomas

Renaud, Jean-Paul

Schwabe, John

Sladek, Frances

Tsai, Ming-Jer

Laudet, Vincent

机构：

[1] Ecole Normale Super Lyon, CNRS, INRA 1237, UMR 5161,Lab Biol Mol Cellule,IFR128 BioSci Lyon, F-69364 Lyon 07, France

[2] Baylor Coll Med, Dept Mol & Cellular Biol, Houston, TX 77030 USA

[3] McGill Univ, Ctr Hlth, Mol Oncol Grp, Montreal, PQ, Canada

[4] Univ Calif San Francisco, Dept Physiol, San Francisco, CA USA

[5] Univ Penn, Sch Med, Div Endocrinol Diabet & Metab, Inst Diabet Obes & Metab, Philadelphia, PA 19104 USA

[6] Univ Queensland, Inst Mol Biosci, St Lucia, Qld, Australia

[7] Karolinska Inst, Ludwig Inst Canc Res, Dept Cell & Mol Biol, Stockholm, Sweden

[8] AliX, Illkirch Graffenstaden, France

[9] MRC, Mol Biol Lab, Cambridge, England

[10] Univ Calif Riverside, Dept Cell Biol & Neurosci, Riverside, CA 92521 USA

来源：

PHARMACOLOGICAL REVIEWS | 2006年 / 58卷 / 04期

关键词：

D O I：

10.1124/pr.58.4.10

中图分类号：

R9 [药学];

学科分类号：

1007 ;

摘要：

Half of the members of the nuclear receptors superfamily are so-called "orphan" receptors because the identity of their ligand, if any, is unknown. Because of their important biological roles, the study of orphan receptors has attracted much attention recently and has resulted in rapid advances that have helped in the discovery of novel signaling pathways. In this review we present the main features of orphan receptors, discuss the structure of their ligand-binding domains and their biological functions. The paradoxical existence of a pharmacology of orphan receptors, a rapidly growing and innovative field, is highlighted.

引用

页码：798 / 836

页数：39

共 142 条

[1] The role of SF1/DAX1 in adrenal and reproductive function [J].

Achermann, JC .

ANNALES D ENDOCRINOLOGIE, 2005, 66 (03) :233-239

[2] REV-ving up the clock [J].

Alvarez, JD ;

Sehgal, A .

DEVELOPMENTAL CELL, 2002, 3 (02) :150-152

[3] Coactivators for the orphan nuclear receptor RORα [J].

Atkins, GB ;

Hu, X ;

Guenther, MG ;

Rachez, C ;

Freedman, LP ;

Lazar, MA .

MOLECULAR ENDOCRINOLOGY, 1999, 13 (09) :1550-1557

[4] The Drosophila orphan nuclear receptor DHR38 mediates an atypical ecdysteroid signaling pathway [J].

Baker, KD ;

Shewchuk, LM ;

Kozlova, T ;

Makishima, M ;

Hassell, A ;

Wisely, B ;

Caravella, JA ;

Lambert, MH ;

Reinking, JL ;

Krause, H ;

Thummel, CS ;

Willson, TM ;

Mangelsdorf, DJ .

CELL, 2003, 113 (06) :731-742

[5] The ERRα orphan nuclear receptor controls morphogenetic movements during zebrafish gastrulation [J].

Bardet, PL ;

Horard, B ;

Laudet, V ;

Vanacker, JM .

DEVELOPMENTAL BIOLOGY, 2005, 281 (01) :102-111

[6] Transcriptional corepression by SHP:: molecular mechanisms and physiological consequences [J].

Båvner, A ;

Sanyal, S ;

Gustafsson, JÅ ;

Treuter, E .

TRENDS IN ENDOCRINOLOGY AND METABOLISM, 2005, 16 (10) :478-488

[7] IDENTIFICATION OF NUCLEAR RECEPTOR MESSENGER-RNAS BY RT-PCR AMPLIFICATION OF CONSERVED ZINC-FINGER MOTIF SEQUENCES [J].

BECKERANDRE, M ;

ANDRE, E ;

DELAMARTER, JF .

BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS, 1993, 194 (03) :1371-1379

[8] Digging deep into the pockets of orphan nuclear receptors: insights from structural studies [J].

Benoit, G ;

Malewicz, M ;

Perlmann, T .

TRENDS IN CELL BIOLOGY, 2004, 14 (07) :369-376

[9] Crystal structure of the ligand-binding domain of the ultraspiracle protein USP, the ortholog of retinoid X receptors in insects [J].

Billas, IML ;

Moulinier, L ;

Rochel, N ;

Moras, D .

JOURNAL OF BIOLOGICAL CHEMISTRY, 2001, 276 (10) :7465-7474

[10] Orphan nuclear receptors - new ligands and new possibilities [J].

Blumberg, B ;

Evans, RM .

GENES & DEVELOPMENT, 1998, 12 (20) :3149-3155

← 1 2 3 4 5 6 7 8 9 10 →