Bifunctional antitumor agents. Derivatives of pyrrolo[9,10-b]phenanthrene - a DNA intercalative delivery template

被引：34

作者：

Jones, GB ^{[1
]}

Mathews, JE ^{[1
]}

机构：

[1] CLEMSON UNIV,GREENVILLE HOSP SYST,MED CHEM LAB,CLEMSON,SC 29634

来源：

TETRAHEDRON | 1997年 / 53卷 / 43期

关键词：

D O I：

10.1016/S0040-4020(97)00991-5

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

The preparation and intercalative ability of the pyrrolo[9, 10-b]phenanthrene nucleus is described. Functionalization bf the nucleus was achieved using standard indole chemistry. The utility of this template as a DNA intercalating drug delivery system is demonstrated by synthesis of a derived bis-chloroethylamine alkylating system and a hybrid DNA interactive enediyne system. (C) 1997 Elsevier Science Ltd.

引用

页码：14599 / 14614

页数：16

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