Cannabidiol as a Potential Treatment for Anxiety Disorders

被引：406

作者：

Blessing, Esther M. ^{[1
]}

Steenkamp, Maria M. ^{[1
]}

Manzanares, Jorge ^{[1
,2
,3
]}

Marmar, Charles R. ^{[1
]}

机构：

[1] NYU, Sch Med, New York, NY 10016 USA

[2] Univ Miguel Hernandez, Inst Neurociencias Alicante, Alicante, Spain

[3] CSIC, Alicante, Spain

来源：

NEUROTHERAPEUTICS | 2015年 / 12卷 / 04期

关键词：

Cannabidiol; Endocannabinoids; Anxiety; Generalized anxiety disorder; Post-traumatic stress disorder; POSTTRAUMATIC-STRESS-DISORDER; ACUTE RESTRAINT STRESS; ELEVATED PLUS-MAZE; COMORBIDITY SURVEY REPLICATION; MARBLE-BURYING BEHAVIOR; ENDOCANNABINOID SYSTEM; 5-HT1A RECEPTORS; PERIAQUEDUCTAL GRAY; CARDIOVASCULAR-RESPONSES; STRIA TERMINALIS;

D O I：

10.1007/s13311-015-0387-1

中图分类号：

R74 [神经病学与精神病学];

学科分类号：

摘要：

Cannabidiol (CBD), a Cannabis sativa constituent, is a pharmacologically broad-spectrum drug that in recent years has drawn increasing interest as a treatment for a range of neuropsychiatric disorders. The purpose of the current review is to determine CBD's potential as a treatment for anxiety-related disorders, by assessing evidence from preclinical, human experimental, clinical, and epidemiological studies. We found that existing preclinical evidence strongly supports CBD as a treatment for generalized anxiety disorder, panic disorder, social anxiety disorder, obsessive-compulsive disorder, and post-traumatic stress disorder when administered acutely; however, few studies have investigated chronic CBD dosing. Likewise, evidence from human studies supports an anxiolytic role of CBD, but is currently limited to acute dosing, also with few studies in clinical populations. Overall, current evidence indicates CBD has considerable potential as a treatment for multiple anxiety disorders, with need for further study of chronic and therapeutic effects in relevant clinical populations.

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收藏

页码：825 / 836

页数：12

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