TMC-171A, B, C and TMC-154, novel polyketide antibiotics produced by Gliocladium sp TC 1304 and TC 1282

被引：21

作者：

Kohno, J ^{[1
]}

Asai, Y ^{[1
]}

Nishio, M ^{[1
]}

Sakurai, M ^{[1
]}

Kawano, K ^{[1
]}

Hiramatsu, H ^{[1
]}

Kameda, N ^{[1
]}

Kishi, N ^{[1
]}

Okuda, T ^{[1
]}

Komatsubara, S ^{[1
]}

机构：

[1] Tanabe Seiyaku Co Ltd, Discovery Res Lab, Toda, Saitama 3358505, Japan

来源：

JOURNAL OF ANTIBIOTICS | 1999年 / 52卷 / 12期

关键词：

D O I：

10.7164/antibiotics.52.1114

中图分类号：

Q81 [生物工程学（生物技术）]; Q93 [微生物学];

学科分类号：

071005 ; 0836 ; 090102 ; 100705 ;

摘要：

Four new antibiotics, TMC-171A (2), B (3), C (4) and TMC-154 (5) have been isolated from the fermentation of fungal strains Gliocladium sp. TC 1304 and TC 1282, respectively. Spectroscopic and degradation studies have shown that TMC-171s and TMC-154 were new members of the TMC-151 class of antibiotics, unique polyketides modified with a D-mannose and a D-mannitol or a D-arabitol. These compounds showed moderate cytotoxicity to various tumor cell lines.

引用

页码：1114 / 1123

页数：10

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