The antiSMASH database, a comprehensive database of microbial secondary metabolite biosynthetic gene clusters

被引：205

作者：

Blin, Kai ^{[1
]}

Medema, Marnix H. ^{[2
]}

Kottmann, Renzo ^{[3
]}

Lee, Sang Yup ^{[1
,4
]}

Weber, Tilmann ^{[1
]}

机构：

[1] Tech Univ Denmark, Novo Nordisk Fdn Ctr Biosustainabil, DK-2800 Lyngby, Denmark

[2] Wageningen Univ, Bioinformat Grp, NL-6708 PB Wageningen, Netherlands

[3] Max Planck Inst Marine Mikrobiol, Microbial Genom & Bioinformat Res Grp, D-28359 Bremen, Germany

[4] Korea Adv Inst Sci & Technol, Dept Chem & Biomol Engn, BK Plus Program 21, Metabol & Biomol Engn Natl Res Lab, Daejeon 34141, South Korea

来源：

NUCLEIC ACIDS RESEARCH | 2017年 / 45卷 / D1期

关键词：

NATURAL-PRODUCTS; RESOURCE; STREPTOMEDB; ANNOTATION; TOOLS;

D O I：

10.1093/nar/gkw960

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

070307 [化学生物学]; 071010 [生物化学与分子生物学];

摘要：

Secondary metabolites produced by microorganisms are the main source of bioactive compounds that are in use as antimicrobial and anticancer drugs, fungicides, herbicides and pesticides. In the last decade, the increasing availability of microbial genomes has established genome mining as a very important method for the identification of their biosynthetic gene clusters (BGCs). One of the most popular tools for this task is antiSMASH. However, so far, antiSMASH is limited to de novo computing results for user-submitted genomes and only partially connects these with BGCs from other organisms. Therefore, we developed the antiSMASH database, a simple but highly useful new resource to browse antiSMASH-annotated BGCs in the currently 3907 bacterial genomes in the database and perform advanced search queries combining multiple search criteria. antiSMASH-DB is available at http://antismash-db.secondarymetabolites.org/.

引用

页码：D555 / D559

页数：5

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