Targeting the interleukin-15/interleukin-15 receptor system in inflammatory autoimmune diseases

被引：64

作者：

Waldmann, TA ^{[1
]}

机构：

[1] NCI, Metab Branch, Ctr Canc Res, NIH, Bethesda, MD 20892 USA

来源：

ARTHRITIS RESEARCH & THERAPY | 2004年 / 6卷 / 04期

关键词：

autoimmune disease; interleukin-15; memory T cells; rheumatoid arthritis;

D O I：

10.1186/ar1202

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

Interleukin (IL)-15 is a dangerous inflammatory cytokine that induces tumor-necrosis factor-alpha, IL-1beta and inflammatory chemokines. It inhibits self-tolerance mediated by IL-2 mediated activation-induced cell death and facilitates maintenance of CD8(+) memory T-cell survival including that of self-directed memory cells. Disordered IL-15 expression has been reported in patients with an array of inflammatory autoimmune diseases. A series of therapeutic agents that inhibit IL-15 action have been introduced, including the soluble IL-15 receptor (IL-15R) alpha chain, mutant IL-15, and antibodies directed against the IL-15 cytokine and against the IL-2R/IL-15R beta subunit used by IL-2 and IL-15.

引用

页码：174 / 177

页数：4

共 22 条

[1] IL-15 plays a major role in the persistence of tax-specific CD8 cells in HAM/TSP patients
Azimi, N
Nagai, M
Jacobson, S
Waldmann, TA
[J]. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 2001, 98 (25) : 14559 - 14564
[2] THE INTERLEUKIN (IL)-2 RECEPTOR-BETA CHAIN IS SHARED BY IL-2 AND A CYTOKINE, PROVISIONALLY DESIGNATED IL-T, THAT STIMULATES T-CELL PROLIFERATION AND THE INDUCTION OF LYMPHOKINE-ACTIVATED KILLER-CELLS
BAMFORD, RN
GRANT, AJ
BURTON, JD
PETERS, C
KURYS, G
GOLDMAN, CK
BRENNAN, J
ROESSLER, E
WALDMANN, TA
[J]. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 1994, 91 (11) : 4940 - 4944
[3] BASLUND B, 2003, ARTHRITIS RHEUM SS, P1706
[4] Role of cytokines in rheumatoid arthritis
Feldmann, M
Brennan, FM
Maini, RN
[J]. ANNUAL REVIEW OF IMMUNOLOGY, 1996, 14 : 397 - 440
[5] CLONING OF A T-CELL GROWTH-FACTOR THAT INTERACTS WITH THE BETA-CHAIN OF THE INTERLEUKIN-2 RECEPTOR
GRABSTEIN, KH
EISENMAN, J
SHANEBECK, K
RAUCH, C
SRINIVASAN, S
FUNG, V
BEERS, C
RICHARDSON, J
SCHOENBORN, MA
AHDIEH, M
JOHNSON, L
ALDERSON, MR
WATSON, JD
ANDERSON, DM
GIRI, JG
[J]. SCIENCE, 1994, 264 (5161) : 965 - 968
[6] Harada S, 1999, ARTHRITIS RHEUM, V42, P1508, DOI 10.1002/1529-0131(199907)42:7<1508::AID-ANR26>3.0.CO
[7] 2-L
[8] Kim YS, 1998, J IMMUNOL, V160, P5742
[9] Control of homeostasis of CD8+ memory T cells by opposing cytokines
Ku, CC
Murakami, M
Sakamato, A
Kappler, J
Marrack, P
[J]. SCIENCE, 2000, 288 (5466) : 675 - 678
[10] IL-15 receptor maintains lymphoid homeostasis by supporting lymphocyte homing and proliferation
Lodolce, JP
Boone, DL
Chai, S
Swain, RE
Dassopoulos, T
Trettin, S
Ma, A
[J]. IMMUNITY, 1998, 9 (05) : 669 - 676

← 1 2 3 →