Cation-π interactions in ligand recognition and catalysis

被引：400

作者：

Zacharias, N ^{[1
]}

Dougherty, DA ^{[1
]}

机构：

[1] CALTECH, Div Chem & Chem Engn, Pasadena, CA 91125 USA

来源：

TRENDS IN PHARMACOLOGICAL SCIENCES | 2002年 / 23卷 / 06期

关键词：

D O I：

10.1016/S0165-6147(02)02027-8

中图分类号：

R9 [药学];

学科分类号：

1007 ;

摘要：

The cation-pi interaction is a potent, general noncovalent binding force that is observed in a wide range of biological contexts. Here, we present an overview of well documented cases in which a cation-pi interaction makes an important contribution to small-molecule recognition at a protein binding site. From these and other studies it is clear that, in addition to the hydrophobic effect, hydrogen bonding and ion pairing, the cation-it interaction must be considered when evaluating drug-receptor interactions.

引用

页码：281 / 287

页数：7

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