Membrane activation: Selective vesicle fusion via small molecule recognition

被引：70

作者：

Gong, Yun ^{[1
]}

Luo, Yumei ^{[1
]}

Bong, Dennis ^{[1
]}

机构：

[1] Ohio State Univ, Dept Chem, Columbus, OH 43210 USA

来源：

JOURNAL OF THE AMERICAN CHEMICAL SOCIETY | 2006年 / 128卷 / 45期

基金：

美国国家科学基金会;

关键词：

D O I：

10.1021/ja0644576

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

We report herein the induction of selective vesicle fusion with biological recognition motifs not natively associated with lipid bilayer fusion, thus broadening the scope of recognition-guided membrane activation. Our system employs vancomycin glycopeptide, coupled to the antimicrobial peptide magainin, and D-Ala-D-Ala-OH dipeptide coupled to a phospholipid derivative, as surface-bound fusogens. Fusion was characterized by dynamic light scattering and FRET experiments with lipid bound fluorophores. We have demonstrated here that appropriately designed membrane anchored molecular recognition motifs have the biomimetic ability to activate specific membrane mergers; this principle has resonance with goals in targeted chemical delivery and nanoscale compartmentalized chemistry. Copyright © 2006 American Chemical Society.

引用

页码：14430 / 14431

页数：2

共 43 条

[1] Structure and functions of channel-forming peptides: Magainins, cecropins, melittin and alamethicin [J].