Quantitation of amphetamine, methamphetamine, and their methylenedioxy derivatives in urine by solid-phase microextraction coupled with electrospray ionization-high-field asymmetric waveform ion mobility spectrometry-mass spectrometry

被引：76

作者：

McCooeye, MA ^{[1
]}

Mester, Z ^{[1
]}

Ells, B ^{[1
]}

Barnett, DA ^{[1
]}

Purves, RW ^{[1
]}

Guevremont, R ^{[1
]}

机构：

[1] Natl Res Council Canada, Inst Natl Measurement Stand, Ottawa, ON K1A 0R6, Canada

来源：

ANALYTICAL CHEMISTRY | 2002年 / 74卷 / 13期

关键词：

D O I：

10.1021/ac011296+

中图分类号：

O65 [分析化学];

学科分类号：

070302 ; 081704 ;

摘要：

Amphetamine, methamphetamine, and their methylenedioxy derivatives have been identified and measured in a human urine matrix using solid-phase microextraction (SPME) and high-field asymmetric waveform ion mobility spectrometry (FAIMS) in combination with electrospray ionization (ESI) and mass spectrometric detection (MS). Limits of detection in human urine between 200 pg/mL and 7.5 ng/mL have been achieved. The use of a simple extraction method, SPME, combined with the high sensitivity and selectivity of ESI-FAIMS-MS eliminates the need for chromatographic separation and allows for very rapid sample processing.

引用

页码：3071 / 3075

页数：5

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