Libraries from natural product-like scaffolds

被引：165

作者：

Boldi, AM ^{[1
]}

机构：

[1] Discovery Partners Int, Discovery Chem Div, San Francisco, CA 94080 USA

来源：

CURRENT OPINION IN CHEMICAL BIOLOGY | 2004年 / 8卷 / 03期

关键词：

D O I：

10.1016/j.cbpa.2004.04.010

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Natural products are an attractive source of varied structures that exhibit potent biological activities, and desirable pharmacological profiles. Since the relatively recent advent of high-throughput organic synthesis in the drug discovery process, several design approaches have been applied to the construction of screening libraries. Libraries of natural-product derivatives, natural-product-like compounds prepared by total synthesis, and libraries derived from natural-products are several types that have been reported.

引用

页码：281 / 286

页数：6

共 45 条

[1] Modern methods to produce natural-product libraries
Abel, U
Koch, C
Speitling, M
Hansske, FG
[J]. CURRENT OPINION IN CHEMICAL BIOLOGY, 2002, 6 (04) : 453 - 458
[2] Natural product-like combinatorial libraries
Abreu, PM
Branco, PS
[J]. JOURNAL OF THE BRAZILIAN CHEMICAL SOCIETY, 2003, 14 (05) : 675 - 712
[3] A solid phase library synthesis of hydroxyindoline-derived tricyclic derivatives by Mitsunobu approach
Arya, P
Wei, CQ
Barnes, ML
Daroszewska, M
[J]. JOURNAL OF COMBINATORIAL CHEMISTRY, 2004, 6 (01): : 65 - 72
[4] Stereoselective diversity-oriented solution and solid-phase synthesis of tetrahydroquinoline-based polycyclic derivatives
Arya, P
Durieux, P
Chen, ZX
Joseph, R
Leek, DM
[J]. JOURNAL OF COMBINATORIAL CHEMISTRY, 2004, 6 (01): : 54 - 64
[5] Arya P, 2001, ANGEW CHEM INT EDIT, V40, P339, DOI 10.1002/1521-3773(20010119)40:2<339::AID-ANIE339>3.0.CO
[6] 2-J
[7] Chemoinformatics methods for systematic comparison of molecules from natural and synthetic sources and design of hybrid libraries
Bajorath, J
[J]. JOURNAL OF COMPUTER-AIDED MOLECULAR DESIGN, 2002, 16 (5-6) : 431 - 439
[8] Solid-phase library synthesis of alkoxyprolines
Boldi, AM
Dener, JM
Hopkins, TP
[J]. JOURNAL OF COMBINATORIAL CHEMISTRY, 2001, 3 (04): : 367 - 373
[9] Natural product guided compound library development
Breinbauer, R
Manger, M
Scheck, M
Waldmann, H
[J]. CURRENT MEDICINAL CHEMISTRY, 2002, 9 (23) : 2129 - 2145
[10] Solid-phase synthesis of dysidiolide-derived protein phosphatase inhibitors
Brohm, D
Philippe, N
Metzger, S
Bhargava, A
Müller, O
Lieb, F
Waldmann, H
[J]. JOURNAL OF THE AMERICAN CHEMICAL SOCIETY, 2002, 124 (44) : 13171 - 13178

← 1 2 3 4 5 →