Maternal immunologic and virologic risk factors for infant human immunodeficiency virus type 1 infection: Findings from the Women and Infants Transmission Study

被引：60

作者：

Pitt, J

Brambilla, D

Reichelderfer, P

Landay, A

McIntosh, K

Burns, D

Hillyer, GV

Mendez, H

Fowler, MG

机构：

[1] SUNY HLTH SCI CTR,DEPT PEDIAT,BROOKLYN,NY 11203

[2] NEW ENGLAND RES INST,WATERTOWN,MA 02172

[3] RUSH PRESBYTERIAN ST LUKES MED CTR,CHILDRENS HOSP,DEPT IMMUNOL & MICROBIOL,DIV INFECT DIS,BOSTON,MA

[4] HARVARD UNIV,SCH MED,DEPT PEDIAT,BOSTON,MA 02115

[5] NICHHD,PEDIAT ADOLESCENT & MATERNAL AIDS BRANCH,NIH,BETHESDA,MD 20892

[6] NIAID,DIV AIDS,BETHESDA,MD 20892

[7] UNIV PUERTO RICO,DEPT MICROBIOL,SAN JUAN,PR 00936

来源：

JOURNAL OF INFECTIOUS DISEASES | 1997年 / 175卷 / 03期

关键词：

D O I：

10.1093/infdis/175.3.567

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

Maternal virus load of human immunodeficiency virus 1 (HIV-1) and maternal immunity are both associated with risk of an infected infant. The interrelationship of these two variables in describing that risk was assessed in a multisite study of 475 mother-infant pairs. Infant infection was associated with low CD4 cell percentage, high CD8, CD8/CD38, and CD8/DR cell percentages, persistently positive HIV-1 cultures, and high HIV-1 titer (P <. 001, .001, .005, .006, .001, and .013, respectively). The association of CD4 cell percentage and increased CD8, CD8/CD38, and CD8/DR cell percentages with transmission was restricted to the 42% of women whose HIV-1 cultures were not persistently positive (all P < .001). Women with at least 1 negative culture and high CD4 cell percentage or low CD8 cell percentage were at very low risk (0-4%) of transmitting HIV-1, while those with always positive cultures transmitted at a high rate (18%-27%), regardless of immune status.

引用

页码：567 / 575

页数：9

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