Uncovering the evolutionary history of innate immunity: The simple metazoan Hydra uses epithelial cells for host defence

被引：168

作者：

Bosch, Thomas C. G. ^{[1
]}

Augustin, Rene ^{[1
]}

Anton-Erxleben, Friederike ^{[1
]}

Fraune, Sebastian ^{[1
]}

Hemmrich, Georg ^{[1
]}

Zill, Holger ^{[1
]}

Rosenstiel, Philip ^{[2
]}

Jacobs, Gunnar ^{[2
]}

Schreiber, Stefan ^{[2
]}

Leippe, Matthias ^{[1
]}

Stanisak, Mareike ^{[1
]}

Groetzinger, Joachim ^{[3
]}

Jung, Sascha ^{[3
]}

Podschun, Rainer ^{[4
]}

Bartels, Joachim ^{[5
]}

Harder, Juergen ^{[5
]}

Schroeder, Jens-M. ^{[5
]}

机构：

[1] Univ Kiel, Inst Zool, D-24118 Kiel, Germany

[2] Univ Kiel, Inst Clin Mol Biol, Kiel, Germany

[3] Univ Kiel, Inst Biochem, D-2300 Kiel, Germany

[4] Univ Kiel, Inst Infect Med, Kiel, Germany

[5] Univ Kiel, Dept Dermatol, Clin Res Unit, Kiel, Germany

来源：

DEVELOPMENTAL AND COMPARATIVE IMMUNOLOGY | 2009年 / 33卷 / 04期

基金：

美国国家科学基金会;

关键词：

Innate immunity; Epithelial defence; Antimicrobial peptides; Toll-like receptors; Hydra; CAENORHABDITIS-ELEGANS; HUMAN BETA-DEFENSIN-3; ANCESTRAL COMPLEXITY; SEQUENCE ALIGNMENT; HUMAN SKIN; SYSTEM; GENES; IDENTIFICATION; BACTERIAL; PEPTIDES;

D O I：

10.1016/j.dci.2008.10.004

中图分类号：

S9 [水产、渔业];

学科分类号：

0908 ;

摘要：

Although many properties of the innate immune system are shared among multicellular animals, the evolutionary origin remains poorly understood. Here we characterize the innate immune system in Hydra, one of the simplest multicellular animals known. In the complete absence of both protective mechanical barriers and mobile phagocytes, Hydra's epithelium is remarkably well equipped with potent antimicrobial peptides to prevent pathogen infection. Induction of antimicrobial peptide production is mediated by the interaction of a leucine-rich repeats (LRRs) domain containing protein with a TIR-domain containing protein lacking LRRs. Conventional Toll-like receptors (TLRs) are absent in the Hydra genome. Our findings support the hypothesis that the epithelium represents the ancient system of host defence. (C) 2008 Elsevier Ltd. All rights reserved.

引用

页码：559 / 569

页数：11

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[1] Pathogen recognition and innate immunity [J].