New biphenol-based, fine-tunable monodentate phosphoramidite ligands for catalytic asymmetric transformations

被引：69

作者：

Hua, ZH ^{[1
]}

Vassar, VC ^{[1
]}

Choi, H ^{[1
]}

Ojima, I ^{[1
]}

机构：

[1] SUNY Stony Brook, Dept Chem, Stony Brook, NY 11794 USA

来源：

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA | 2004年 / 101卷 / 15期

关键词：

D O I：

10.1073/pnas.0307101101

中图分类号：

O [数理科学和化学]; P [天文学、地球科学]; Q [生物科学]; N [自然科学总论];

学科分类号：

07 ; 0710 ; 09 ;

摘要：

Monodentate phosphoramidite ligands have been developed based on enantiopure 6,6'-dimethylbiphenols with axial chirality. These chiral ligands are easy to prepare and flexible for modifications. The fine-tuning capability of these ligands plays a significant role in achieving high enantioselectivity in the asymmetric hydro-formylation of allyl cyanide and the conjugate addition of diethylzinc to cycloalkenones.

引用

页码：5411 / 5416

页数：6

共 31 条

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