Regulated necrosis: the expanding network of non-apoptotic cell death pathways

被引：1344

作者：

Vanden Berghe, Tom ^{[1
]}

Linkermann, Andreas ^{[2
]}

Jouan-Lanhouet, Sandrine ^{[1
]}

Walczak, Henning ^{[3
]}

Vandenabeele, Peter ^{[1
]}

机构：

[1] Univ Ghent, Flanders Inst Biotechnol VIB, Inflammat Res Ctr, Mol Signaling & Cell Death Unit, B-9052 Ghent, Belgium

[2] Univ Kiel, Div Nephrol & Hypertens, D-24105 Kiel, Germany

[3] UCL, UCL Canc Inst, Ctr Cell Death Canc & Inflammat CCCI, London WC1E 6BT, England

来源：

NATURE REVIEWS MOLECULAR CELL BIOLOGY | 2014年 / 15卷 / 02期

基金：

英国惠康基金; 欧洲研究理事会;

关键词：

MITOCHONDRIAL PERMEABILITY TRANSITION; MIXED LINEAGE KINASE; DOMAIN-LIKE PROTEIN; KAPPA-B ACTIVATION; CYCLOPHILIN-D; OXIDATIVE STRESS; REPERFUSION INJURY; IN-VIVO; MOLECULAR-MECHANISMS; POLY(ADP-RIBOSE) POLYMERASE;

D O I：

10.1038/nrm3737

中图分类号：

Q2 [细胞生物学];

学科分类号：

071009 ; 090102 ;

摘要：

Cell death research was revitalized by the understanding that necrosis can occur in a highly regulated and genetically controlled manner. Although RIPK1 (receptor-interacting protein kinase 1)- and RIPK3-MLKL (mixed lineage kinase domain-like)-mediated necroptosis is the most understood form of regulated necrosis, other examples of this process are emerging, including cell death mechanisms known as parthanatos, oxytosis, ferroptosis, NETosis, pyronecrosis and pyroptosis. Elucidating how these pathways of regulated necrosis are interconnected at the molecular level should enable this process to be therapeutically targeted.

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收藏

页码：134 / 146

页数：13

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