Drug metabolism in the skin

被引:20
作者
Baron, Jens M. [1 ]
Merk, Hans F. [1 ]
机构
[1] Rhein Westfal TH Aachen, Univ Hosp, Dept Dermatol, Pauwelsstr 30, D-52074 Aachen, Germany
关键词
D O I
10.1097/00130832-200108000-00002
中图分类号
R392 [医学免疫学];
学科分类号
100102 ;
摘要
The skin performs a wide range of active metabolic functions including xenobiotic metabolism involving metabolizing enzymes specific to the skin. In this review we focus on the role of drug metabolism: (i) in allergic reactions to substances of low molecular weight; (ii) in cutaneous vitamin A and D-3 metabolism and its modulation; (iii) in the interaction of transport and metabolic enzymes in skin cells; and (iv) on novel tools for the measurement of drug metabolism in various compartments of the human skin. (C) 2001 Lippincott Williams & Wilkins.
引用
收藏
页码:287 / 291
页数:5
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