Going the distance, or not, with neurotrophin signals

被引：27

作者：

Reichardt, LF

Mobley, WC

机构：

[1] Univ Calif San Francisco, Program Neurosci, Dept Phys, San Francisco, CA 94143 USA

[2] Univ Calif San Francisco, Program Neurosci, Howard Hughes Med Inst, San Francisco, CA 94143 USA

[3] Stanford Univ, Inst Neurosci, Stanford, CA 94305 USA

[4] Stanford Univ, Dept Neurol & Neurol Sci, Stanford, CA 94305 USA

来源：

CELL | 2004年 / 118卷 / 02期

关键词：

D O I：

10.1016/j.cell.2004.07.008

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

NGF and NT-3 both signal through TrkA receptors on the axons of developing sympathetic neurons, but while NGF supports survival and differentiation, NT-3 does not. In this issue of Cell, the difference is explained as the ability of NGF, but not NT-3, to induce internalization and retrograde transport of activated TrkA (Kuruvilla et al., 2004).

引用

收藏

页码：141 / 143

页数：3

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