N-(3,4-Dimethylphenyl)-4-hydroxy-2-methyl-2H-1,2-benzothiazine-3-carboxamide 1,1-dioxide

被引：1

作者：

Siddiqui, Waseeq Ahmad ^{[1
]}

Ali, Muhammad ^{[1
]}

Zia-ur-Rehman, Muhammad ^{[2
]}

Sharif, Saima ^{[3
]}

Tizzard, Graham John ^{[4
]}

机构：

[1] Univ Sargodha, Dept Chem, Sargodha, Pakistan

[2] Appl Chem Res Ctr, Lahore 54600, Pakistan

[3] Univ Educ, Div Sci & Technol, Lahore 54770, Pakistan

[4] Univ Southampton, Sch Chem, Southampton SO9 5NH, Hants, England

来源：

ACTA CRYSTALLOGRAPHICA SECTION E-STRUCTURE REPORTS ONLINE | 2009年 / 65卷

关键词：

D O I：

10.1107/S1600536809010058

中图分类号：

O7 [晶体学];

学科分类号：

0702 ; 070205 ; 0703 ; 080501 ;

摘要：

1,2-Benzothiazines similar to the title compound, C18H18N2O4S, are well known in the literature for their biological activities and are used as medicines in the treatment of inflammation and rheumatoid arthritis. The thiazine ring adopts a distorted half-chair conformation. The enolic H atom is involved in an intramolecular O-H center dot center dot center dot O hydrogen bond, forming a six-membered ring. In the crystal, molecules arrange themselves into centrosymmetric dimers by means of pairs of weak intermolecular N-H center dot center dot center dot O hydrogen bonds.

引用

页码：O900 / U3226

页数：12

共 12 条

[1] 1,2-Benzothiazine 1,1-dioxide α-ketoamide analogues as potent calpain I inhibitors [J].