2,3-benzodiazepin-1,4-diones as peptidomimetic inhibitors of γ-secretase

被引：28

作者：

Prasad, CVC

Vig, S

Smith, DW

Gao, Q

Polson, CT

Corsa, JA

Guss, VL

Loo, A

Barten, DM

Zheng, M

Felsenstein, KM

机构：

[1] Bristol Myers Squibb Co, Pharmaceut Res Inst, Dept Discovery Chem, Wallingford, CT 06492 USA

[2] Bristol Myers Squibb Pharamaceut Res Inst, Dept Analyt R&D, Wallingford, CT 06492 USA

[3] Bristol Myers Squibb Co, Pharmaceut Res Inst, Dept Neurosci Biol, Wallingford, CT 06492 USA

[4] Bristol Myers Squibb Co, Pharmaceut Res Inst, Dept Drug Metab & Pharmacokinet, Wallingford, CT 06492 USA

来源：

BIOORGANIC & MEDICINAL CHEMISTRY LETTERS | 2004年 / 14卷 / 13期

关键词：

D O I：

10.1016/j.bmcl.2004.04.056

中图分类号：

R914 [药物化学];

学科分类号：

100701 ;

摘要：

2,3-Benzodiazepin-1,4-diones were designed as peptidomimetics at the carboxy terminus of hydroxyamides. Inhibition of brain Abeta production was improved by one of the compounds containing constrained modification. (C) 2004 Elsevier Ltd. All rights reserved.

引用

页码：3535 / 3538

页数：4

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