IMRT: a review and preview

被引:336
作者
Bortfeld, Thomas
机构
[1] Massachusetts Gen Hosp, Dept Radiat Oncol, Boston, MA 02114 USA
[2] Harvard Univ, Sch Med, Boston, MA 02114 USA
关键词
D O I
10.1088/0031-9155/51/13/R21
中图分类号
R318 [生物医学工程];
学科分类号
0831 ;
摘要
The very first cornerstone paper on intensity-modulated radiation therapy (IMRT) was published in Physics in Medicine and Biology, and many seminal IMRT works have since appeared in this journal. Today IMRT is a widely used clinical treatment modality in many countries. This contribution to the 50th anniversary issue reviews the physical, mathematical, and technological milestones that have facilitated the clinical implementation and success of IMRT. In particular, the basic concepts and developments of both IMRT treatment planning ('inverse planning') and the delivery of cone-beam IMRT with a multileaf collimator from a fixed number of static beam directions are discussed. An outlook into the future of IMRT concludes the paper.
引用
收藏
页码:R363 / R379
页数:17
相关论文
共 68 条
[31]   Intensity-modulated radiotherapy - A large scale multi-criteria programming problem [J].
Karl-Heinz Küfer ;
Alexander Scherrer ;
Michael Monz ;
Fernando Alonso ;
Hans Trinkaus ;
Thomas Bortfeld ;
Christian Thieke .
OR Spectrum, 2003, 25 (2) :223-249
[32]   Operations research applied to radiotherapy, an NCI-NSF-sponsored workshop - February 7-9, 2002 [J].
Langer, M ;
Lee, EK ;
Deasy, JO ;
Rardin, RL ;
Deye, JA .
INTERNATIONAL JOURNAL OF RADIATION ONCOLOGY BIOLOGY PHYSICS, 2003, 57 (03) :762-768
[33]   Improved leaf sequencing reduces segments or monitor units needed to deliver IMRT using multileaf collimators [J].
Langer, M ;
Thai, V ;
Papiez, L .
MEDICAL PHYSICS, 2001, 28 (12) :2450-2458
[34]   ROTATION THERAPY USING A NOVEL HIGH-GRADIENT FILTER [J].
LAX, I ;
BRAHME, A .
RADIOLOGY, 1982, 145 (02) :473-478
[35]   Towards multidimensional radiotherapy (MD-CRT): Biological imaging and biological conformality [J].
Ling, CC ;
Humm, J ;
Larson, S ;
Amols, H ;
Fuks, Z ;
Leibel, S ;
Koutcher, JA .
INTERNATIONAL JOURNAL OF RADIATION ONCOLOGY BIOLOGY PHYSICS, 2000, 47 (03) :551-560
[36]   Conformal radiation treatment of prostate cancer using inversely-planned intensity-modulated photon beams produced with dynamic multileaf collimation [J].
Ling, CC ;
Burman, C ;
Chui, CS ;
Kutcher, GJ ;
Leibel, SA ;
LoSasso, T ;
Mohan, R ;
Bortfeld, T ;
Reinstein, L ;
Spirou, S ;
Wang, XH ;
Wu, QW ;
Zelefsky, M ;
Fuks, Z .
INTERNATIONAL JOURNAL OF RADIATION ONCOLOGY BIOLOGY PHYSICS, 1996, 35 (04) :721-730
[37]   Intensity modulation methods for proton radiotherapy [J].
Lomax, A .
PHYSICS IN MEDICINE AND BIOLOGY, 1999, 44 (01) :185-205
[38]   TOMOTHERAPY - A NEW CONCEPT FOR THE DELIVERY OF DYNAMIC CONFORMAL RADIOTHERAPY [J].
MACKIE, TR ;
HOLMES, T ;
SWERDLOFF, S ;
RECKWERDT, P ;
DEASY, JO ;
YANG, J ;
PALIWAL, B ;
KINSELLA, T .
MEDICAL PHYSICS, 1993, 20 (06) :1709-1719
[39]  
MCSHAN DL, 2004, 14 INT C US COMP RAD, P232
[40]   Intensity-modulated radiation therapy use in the U.S, 2004 [J].
Mell, LK ;
Mehrotra, AK ;
Mundt, AJ .
CANCER, 2005, 104 (06) :1296-1303