Pulmonary toxicity of inhaled aerosolized prostacyclin therapy - An observational study

被引：21

作者：

van Heerden, PV

Caterina, P

Filion, P

Spagnolo, DV

Gibbs, NM

机构：

[1] Sir Charles Gairdiner Hosp, Dept Intens Care, PathCtr, QEII Med Ctr, Perth, WA, Australia

[2] Sir Charles Gairdiner Hosp, Dept Histopathol & Anaesthesia, PathCtr, QEII Med Ctr, Perth, WA, Australia

[3] Univ Western Australia, Dept Pharmacol, Perth, WA 6009, Australia

来源：

ANAESTHESIA AND INTENSIVE CARE | 2000年 / 28卷 / 02期

关键词：

prostaglandin : prostacyclin; inhalational; toxicity; pulmonary; prostacyclin;

D O I：

10.1177/0310057X0002800206

中图分类号：

R614 [麻醉学];

学科分类号：

100217 ;

摘要：

Large white/landrace piglets (mass 11 to 21 kg) were exposed to aerosolized alkaline glycine diluent (n=2) or inhaled aerosolized prostacyclin (n=2) for five to eight hours. Pigs receiving these aerosols developed mild acute sterile tracheitis, involving the superficial layers of the trachea shown histologically and ultrastructurally. Pigs receiving the diluent aerosol also showed mild inflammatory changes in the bronchioles, These findings suggest caution with the use of high volumes of aerosolized alkaline glycine diluent during inhaled aerosolized prostacyclin therapy.

引用

页码：161 / 166

页数：6

共 40 条

[1] Cardiovascular and pulmonary effects of aerosolized prostacyclin administration in severe respiratory failure using a ventilator nebulization system [J].