Identification of trace element - Containing proteins in genomic databases

被引：40

作者：

Gladyshev, VN ^{[1
]}

Kryukov, GV

Fomenko, DE

Hatfield, DL

机构：

[1] Univ Nebraska, Dept Biochem, Lincoln, NE 68588 USA

[2] NCI, Canc Res Ctr, Lab Canc Prevent, Sect Mol Biol Selenium,NIH, Bethesda, MD 20892 USA

来源：

ANNUAL REVIEW OF NUTRITION | 2004年 / 24卷

关键词：

bioinformatics; metal-containing proteins; selenium; selenoprotein; selenoproteome;

D O I：

10.1146/annurev.nutr.24.012003.132241

中图分类号：

R15 [营养卫生、食品卫生]; TS201 [基础科学];

学科分类号：

100403 ;

摘要：

Development of bioinformatics tools provided researchers with the ability to identify full sets of trace element-containing proteins in organisms for which complete genomic sequences are available. Recently, independent bioinformatics methods were used to identify all, or almost all, genes encoding selenocysteine-containing proteins in human, mouse, and Drosophila genomes, characterizing entire selenoproteomes in these organisms. It also should be possible to search for entire sets of other trace element-associated proteins, such as metal-containing proteins, although methods for their identification are still in development.

引用

收藏

页码：579 / 596

页数：20

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